Evidence map›Paper›PMID 31315589›Full record

ArticleBMC neurology2019

Influence of paroxysmal sympathetic hyperactivity (PSH) on the functional outcome of neurological early rehabilitation patients: a case control study.

Alan Totikov, Melanie Boltzmann, Simone B Schmidt, Jens D Rollnik

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 18 citations in OpenAlex.

  1. Trial
  2. Article
  3. Observational
  4. Review
  5. Observational
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Alan TotikovBDH-Clinic Hessisch Oldendorf, Institute for Neurorehabilitation Research, Associated Institute of the Hannover Medical School, Greitstraße 18-28, 31840, Hessisch Oldendorf, Germany.
Melanie BoltzmannBDH-Clinic Hessisch Oldendorf, Institute for Neurorehabilitation Research, Associated Institute of the Hannover Medical School, Greitstraße 18-28, 31840, Hessisch Oldendorf, Germany. m.boltzmann@nkho.de.ORCID http://orcid.org/0000-0003-2722-5624
Simone B SchmidtBDH-Clinic Hessisch Oldendorf, Institute for Neurorehabilitation Research, Associated Institute of the Hannover Medical School, Greitstraße 18-28, 31840, Hessisch Oldendorf, Germany.
Jens D RollnikBDH-Clinic Hessisch Oldendorf, Institute for Neurorehabilitation Research, Associated Institute of the Hannover Medical School, Greitstraße 18-28, 31840, Hessisch Oldendorf, Germany.
Medizinische Hochschule Hannover · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundParoxysmal Sympathetic Hyperactivity (PSH) is a frequently observed condition among critically ill patients on intensive care units. According to different studies, PSH is associated with worse recovery and increased mortality in acute-care facilities. In this monocentric, retrospective case-control study, we investigated whether this association also applies to post-acute neurological early rehabilitation.

methodsThe study included n = 387 patients, admitted to an intensive care or intermediate care unit within 1 year (2016). Among these, 97 patients showed clinical signs of PSH. For each patient with PSH, a patient without PSH was identified, controlling for age, gender, functional and respiratory status upon admission. However, for 25 patients with PSH, there was no suitable control patient fulfilling all defined matching criteria. Primary outcome was type of discharge, dichotomized into favorable (follow-up rehabilitation) and unfavorable outcome (all others). Secondary outcome measures were functional and respiratory status, number of secondary diagnoses, duration of treatment interruptions and length of stay at discharge.

resultsAbout 25% of neurological early rehabilitation patients showed clinical signs of PSH. A young age (OR = 0.94; CI = 0.91-0.97) and less severe PSH symptoms (OR = 0.79; CI = 0.69-0.90) were independent predictors of a favorable outcome. In addition, severity of PSH symptoms was associated with weaning duration, while the occurrence of PSH symptoms alone had no influence on most secondary outcome variables. The treatment on intermediate care units proved to be longer for patients with PSH symptoms, only.

conclusionsPatients with PSH represent a large group of neurological early rehabilitation patients. Overall, we did not find PSH-related differences in most of the examined outcome measures. However, severe PSH symptoms seem to be associated with poorer outcome and longer treatment on intermediate care units, in order to prevent possible complications.

Indexed as

Neurological RehabilitationAgedAutonomic Nervous System DiseasesCase-Control StudiesFemaleHospitalizationHumansIntensive Care UnitsMaleMiddle AgedOutcome Assessment, Health CareRetrospective StudiesCase control studyNeurological early rehabilitationOutcomeParoxysmal sympathetic hyperactivity (PSH)

Identifiers

PMID31315589
PMCPMC6636123
OpenAlexW2959649014

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.