ArticleJournal of the American Heart Association2019
Ischemic Stroke in Adults With Congenital Heart Disease: A Population-Based Cohort Study.
Article in Journal of the American Heart Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Risk of stroke in patients with congenital heart disease: a systematic review and meta-analysis.BMC neurology · 2024Pooled it
- A rare case of non-obstructed total anomalous pulmonary venous connection with a giant superior vena cava aneurysm complicated by acute young ischemic stroke.BMC cardiovascular disorders · 2026Article
- Cardiorenal Biomarkers and Cerebrovascular Risk in Patients with Congenital Heart Disease.Journal of clinical medicine · 2026Article
- Clinical Characteristics in Adult Congenital Heart Disease Patients With Acute Stroke - A Retrospective Analysis.Circulation reports · 2025Article
- Global, regional, and national epidemiology of ischemic stroke from 1990 to 2021.European journal of neurology · 2024Article
- Ischemic Stroke in Adults With Congenital Heart Disease: Cumulative Incidence and Associated Factors.Journal of the American Heart Association · 2024Article
- Incidence and Predictors of Stroke in Australian Adults With Congenital Heart Disease (2000-2017).Journal of the American Heart Association · 2024Article
- Ischemic Stroke in Patients With Congenital Heart Disease and Atrial Fibrillation.Journal of the American Heart Association · 2024Article
- Reducing Rates and Risk of Stroke in Adults With Congenital Heart Disease: What Can We Do Now, and What Should We Do Next?Journal of the American Heart Association · 2024Article
- "We have dealt with so much. There's more coming?": Improving Knowledge About Brain Health in Adults Living With Congenital Heart Disease.CJC pediatric and congenital heart disease · 2024Article
- Association of the blood urea nitrogen to serum albumin ratio and all-cause mortality in critical ill acute ischemic stroke patients: a retrospective cohort study of MIMIC-IV database 3.0.Frontiers in nutrition · 2024Article
- Biological Age in Congenital Heart Disease-Exploring the Ticking Clock.Journal of cardiovascular development and disease · 2023Review
- Unipolar atrial electrogram morphology is affected by age: evidence from high-resolution epicardial mapping.Annals of medicine · 2023Article
- Design and Harmonization Approach for the Multi-Institutional Neurocognitive Discovery Study (MINDS) of Adult Congenital Heart Disease (ACHD) Neuroimaging Ancillary Study: A Technical Note.Journal of cardiovascular development and disease · 2023Article
- Atrial Fibrillation in Adult Congenital Heart Increase Ischemic Stroke Risk Even at Low CHAReviews in cardiovascular medicine · 2023Article
- Stroke and systemic embolism in adult congenital heart disease.International journal of cardiology. Congenital heart disease · 2023Review
- Lifetime risk of comorbidity in patients with simple congenital heart disease: a Danish nationwide study.European heart journal · 2023Article
- Grand challenges in pediatric stroke.Frontiers in stroke · 2023Article
- Major Adverse Cardiovascular Events in Korean Congenital Heart Disease Patients: A Nationwide Age- and Sex-Matched Case-Control Study.Yonsei medical journal · 2022Article
- Impaired Neurovascular Function Underlies Poor Neurocognitive Outcomes and Is Associated with Nitric Oxide Bioavailability in Congenital Heart Disease.Metabolites · 2022Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Congenital heart disease (CHD) is associated with risk factors for ischemic stroke including cardiac arrhythmias and heart failure. However, few long-term follow-up data exist on ischemic stroke risk and associated mortality in adults with CHD. Methods and Results Using Danish nationwide registries, we identified individuals aged ≥18 years diagnosed with CHD, at any age, from 1963 to 2017 and a sex and birth year-matched (1:10) general population comparison cohort. We computed risks, as well as sex and birth year-adjusted hazard ratios (aHRs) for ischemic stroke and 30-day post-stroke mortality in CHD adults compared with the general population. Analyses were stratified according to age <60 years (young) and ≥60 years (older). We identified 16 836 adults with CHD. The risk of ischemic stroke at age 60 years was 7.4% in the CHD cohort and 2.9% in the general population cohort. The adjusted hazard ratios for ischemic stroke compared with the general population was 3.8 (95% CI: 3.3-4.3) in young CHD adults and 1.6 (95% CI: 1.4-1.9) in older CHD adults. The adjusted hazard ratios for post-stroke mortality compared with the general population was 2.3 (95% CI: 1.2-4.4) in young CHD adults and 1.3 (95% CI: 0.9-1.9) in older CHD adults. Conclusions Both younger and older CHD adults have an increased risk of ischemic stroke and by 60 years of age 7.4% of CHD adults will have had an ischemic stroke. Post-stroke mortality was also increased in CHD adults compared with the general population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.