Evidence map›Paper›PMID 31315444›Full record

ArticleBiological research for nursing2019

Influence of Inflammatory and Oxidative Stress Pathways on Longitudinal Symptom Experiences in Children With Leukemia.

Marilyn J Hockenberry, Wei Pan, Michael E Scheurer, Mary C Hooke, Olga Taylor, Kari Koerner, David Montgomery, Susan Whitman, Pauline Mitby, Ida Moore

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In one paragraph

Article in Biological research for nursing, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Marilyn J Hockenberry1 School of Nursing, Duke University, Durham, NC, USA.
Wei Pan1 School of Nursing, Duke University, Durham, NC, USA.ORCID 0000-0003-2410-9935
Michael E Scheurer2 Baylor College of Medicine, Houston, TX, USA.
Mary C Hooke4 School of Nursing, University of Minnesota, Minneapolis, MN, USA.
Olga Taylor2 Baylor College of Medicine, Houston, TX, USA.
Kari Koerner5 College of Nursing, University of Arizona, Tucson, AZ, USA.
David Montgomery5 College of Nursing, University of Arizona, Tucson, AZ, USA.
Susan Whitman5 College of Nursing, University of Arizona, Tucson, AZ, USA.
Pauline Mitby6 Children's Minnesota, Minneapolis, MN, USA.
Ida Moore5 College of Nursing, University of Arizona, Tucson, AZ, USA.
University of Arizona · USBaylor College of Medicine · USDuke University · USMinnesota West Community & Technical College · USUniversity of Minnesota · US

Funding

Rational Combined Inhibition of NF-kB and EGFR to Optimize Lung Cancer TreatmentR01CA169338 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BIVONA, TREVER G · 2013 to 2023
$3.4M
NCI NIH HHS R01 CA169338
6 · The paper itself

Abstract

purposeThe purpose of this study was to explore the influence of oxidative stress (F2-isoprostanes) and inflammatory (interleukin [IL]-8) biomarkers on symptom trajectories during the first 18 months of childhood leukemia treatment.

methodA repeated-measures design was used to evaluate symptoms experienced by 218 children during treatment. A symptom cluster (fatigue, pain, and nausea) was explored over four time periods: initiation of post-induction therapy, 4 and 8 months into post-induction therapy, and the beginning of maintenance therapy (12 months postinduction). F2-isoprostanes and IL-8 were evaluated in cerebrospinal fluid (CSF) samples collected at baseline (diagnosis) and then at the four time periods. The longitudinal relationships of these biomarkers with the symptom cluster were examined using the longitudinal parallel process.

resultsPain and fatigue levels were highest during the post-induction phases of treatment and decreased slightly during maintenance therapy, while nausea scores were relatively stable. Even in the later phases of treatment, children continued to experience symptoms. CSF levels of the biomarkers increased during the post-induction phases of treatment. Early increases in the biomarkers were associated with more severe symptoms during the same period; patients who had increased biomarkers over time also experienced more severe symptoms over time.

conclusionsFindings reveal that children experienced symptoms throughout the course of leukemia treatment and support hypothesized longitudinal relationships of oxidative stress and inflammatory biomarkers with symptom severity. Activation of the biomarker pathways during treatment may explain underlying mechanisms of symptom experiences and identify which children are at risk for severe symptoms.

Indexed as

AdolescentBiomarkersChildChild, PreschoolF2-IsoprostanesFatigueFemaleHumansLeukemiaLongitudinal StudiesMaleNauseaOxidative StressPainSyndromeBiomarkersF2-Isoprostaneschildhood leukemiainflammatory biomarkerlongitudinal parallel processoxidative stress biomarkersymptom trajectory

Identifiers

PMID31315444
PMCPMC6854429
OpenAlexW2964287590

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.