ArticleMedical physics2019
A second-generation virtual-pinhole PET device for enhancing contrast recovery and improving lesion detectability of a whole-body PET/CT scanner.
Article in Medical physics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Development of a Prototype AWSM-PET Device for Augmented Whole-Body PET Imaging and Initial Human Study.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026Article
- Performance evaluation of the ACTIVE 7 MAX benchtop preclinical PET scanner in accordance with the NEMA NU 4-2008 standard.EJNMMI physics · 2025Article
- A data-driven approach for spatial alignment of PET add-on detectors with sub-millimeter accuracy.Physics in medicine and biology · 2025Article
- High-resolution Imaging Using Virtual-Pinhole PET Concept.PET clinics · 2024Review
- System resolution versus image uncertainty for positron emission tomography scanners.Journal of medical imaging (Bellingham, Wash.) · 2022Article
- Development and Characterization of Modular Readout Design for Two-Panel Head-and-Neck Dedicated PET System Based on CZT Detectors.IEEE transactions on radiation and plasma medical sciences · 2022Article
- Self-Collimating SPECT With Multi-Layer Interspaced Mosaic Detectors.IEEE transactions on medical imaging · 2021Article
- Multiplexing Readout for Time-of-Flight (TOF) PET Detectors Using Striplines.IEEE transactions on radiation and plasma medical sciences · 2021Article
- Augmented Whole-Body Scanning via Magnifying PET.IEEE transactions on medical imaging · 2020Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeWe have developed a second-generation virtual-pinhole (VP) positron emission tomography (PET) device that can position a flat-panel PET detector around a patient's body using a robotic arm to enhance the contrast recovery coefficient (CRC) and detectability of lesions in any region-of-interest using a whole-body PET/computed tomography (CT) scanner.
methodsWe constructed a flat-panel VP-PET device using 32 high-resolution detectors, each containing a 4
resultsThe repeatability in positioning the flat-panel detectors using a robotic arm is better than 0.15 mm in all three directions. Experimental results show that the average CRC of 3.3, 4.3, and 6.0 mm diameter tumors was 0.82%, 2.90%, and 5.25%, respectively, when measured by the native scanner. The corresponding CRC was 2.73%, 6.21% and 10.13% when imaged by the VP-PET insert device with the flat-panel detector under the torso phantom. These values may be further improved to 4.31%, 9.65% and 18.01% by a future dual-panel VP-PET insert device if DOI detectors are employed to triple its detector efficiency. Monte Carlo simulation results show that the tumor detectability can be improved by a VP-PET device that has a single flat-panel detector. The improvement is greater if the VP-PET device employs a dual-panel design.
conclusionsWe have developed a prototype flat-panel VP-PET device and integrated it with a clinical PET/CT scanner. It significantly enhances the contrast of lesions, especially for those that are borderline detectable by the native scanner, within regions-of-interest specified by users. Simulation demonstrated the enhancement in lesion detectability with the VP-PET device. This technology may become a cost-effective solution for organ-specific imaging tasks.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.