ArticleAging2019
The positive impacts of early-life education on cognition, leisure activity, and brain structure in healthy aging.
Article in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
67 citing papers in PubMed.
- Reserves, Injury Severity, and Outcomes in Traumatic Brain Injury: A CENTER-TBI Observational Study.Annals of clinical and translational neurology · 2026Article
- Cerebral amyloid associated with global cognition is differentially moderated by pulse pressure across education levels in The 90+ Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Region-specific vulnerability to vascular risk factors and modifiable protective influences on white matter hyperintensities.Communications medicine · 2026Article
- Explainable Artificial Intelligence to Predict Neurocognitive Disorder Progression in Multiple Sclerosis Using MRI and Clinical Data.European journal of neurology · 2026Article
- Machine learning algorithm reveals neurodevelopmental signatures of combined family income and neighborhood disadvantage in adolescents.Scientific reports · 2026Article
- Exploring the association and mediation between educational attainment and intracerebral hemorrhage: an integrated Mendelian randomization and global burden of disease analysis.Neurosurgical review · 2025Article
- Brain Functional and Structural Changes of Breast Cancer After Chemotherapy: A Systematic Review and Meta-analysis.Neuropsychology review · 2025Review
- Article
- Does education promote resilience and brain health in those with exceptional longevity? The LifeAfter90 study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Higher Education Influences Stroop Performance in Non-Demented Older Adults: The Mediating Role of Resting-State Brain Activity.Clinical and translational science · 2025Article
- Article
- Intrinsic brain functional connectivity mediates the relationship between psychological resilience and cognitive decline in ageing.GeroScience · 2025Article
- The correlation between high temperature and cognitive function: a CHARLS 2018 cross-sectional study.Archives of public health = Archives belges de sante publique · 2025Article
- Virtual Life Story Club Intervention to Improve Loneliness and Apathy in Community-Dwelling Older Adults: Protocol for a Mixed Methods Feasibility Study.JMIR research protocols · 2025Article
- How does educational attainment affect self-rated health among middle-aged and older adults in China? The role of leisure participation and Hukou system.BMC public health · 2025Article
- Associations of diet patterns with successful aging, longevity, and extreme longevity: a prospective cohort study among Chinese adults 65 years or older.European journal of nutrition · 2025Article
- Diverging cognitive benefits from education between rural and urban middle-aged and older adults in the USA.BJPsych open · 2025Article
- Exploring the impact of pregnancy on cognitive function: a comparative study in a low-income setting.BMC pregnancy and childbirth · 2025Article
- Interrupted Learning across the Lifespan.Human development · 2025Article
- Association Between Lifestyle at Different Life Periods and Brain Integrity in Older Adults.Neurology · 2025Observational
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Education in people's early lives are positively related to their cognitive function, but its modulating effects on detailed cognition domains, its interaction with leisure activities and the associated brain changes have yet to be investigated. This report used data from 659 cognitively normal community dwelling elderly who completed neuropsychological tests, leisure activities measurement, and 78 of them underwent structural and diffusion MRI scans. We found that: (i) the highly educated elderly had a better cognitive functioning in multi-domains, higher frequencies of participation in knowledge-related leisure activities, and slower age-related reductions of executive function; (ii) the intellectual and social types of leisure activities mediated the association between education and multiple cognitive domains, including memory, language, attention and executive function; (iii) there was a significant age by education interaction on the gray matter volume of the anterior brain regions and white matter integrity; and (iv) the interaction between age and education affected cognition indirectly through white matter integrity analyzed using structural equation model. Overall, our results revealed that high education in early life served as a protective factor in aging that may help to postpone cognitive and brain reserve decline in cognitively normal aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.