Evidence map›Paper›PMID 31315046›Full record

ArticleCell reports2019

Identification of a Core Amino Acid Motif within the α Subunit of GABA

Anna J Nathanson, Yihui Zhang, Joshua L Smalley, Thomas A Ollerhead, Miguel A Rodriguez Santos, Peter M Andrews, Heike J Wobst, Yvonne E Moore, Nicholas J Brandon, Rochelle M Hines and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 19 citations in OpenAlex.

  1. Dorsal raphe dopaminergic neurons target CaMKIITranslational psychiatry · 2024
    Article
  2. Article
  3. GABA system as the cause and effect in early development.Neuroscience and biobehavioral reviews · 2024
    Review
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  15. Inhibitory Synapse Formation at the Axon Initial Segment.Frontiers in molecular neuroscience · 2019
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Anna J NathansonDepartment of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA.
Yihui ZhangDepartment of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA.
Joshua L SmalleyDepartment of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA.
Thomas A OllerheadDepartment of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA.
Miguel A Rodriguez SantosDepartment of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA.
Peter M AndrewsDepartment of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA.
Heike J WobstAstraZeneca Neuroscience, IMED Biotech Unit, R&D, Boston, MA 02451, USA.
Yvonne E MooreDepartment of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA.
Nicholas J BrandonAstraZeneca Tufts Laboratory for Basic and Translational Neuroscience, Boston, MA 02111, USA; AstraZeneca Neuroscience, IMED Biotech Unit, R&D, Boston, MA 02451, USA.
Rochelle M HinesDepartment of Psychology, University of Nevada Las Vegas, Las Vegas, NV 89154, USA.
Paul A DaviesDepartment of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA.
Stephen J MossDepartment of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA; AstraZeneca Tufts Laboratory for Basic and Translational Neuroscience, Boston, MA 02111, USA; Department of Neuroscience, Physiology and Pharmacology, University College, London WC1E 6BT, UK. Electronic address: stephen.moss@tufts.edu.
Tufts University · USAstraZeneca (United States) · USUniversity of Nevada, Las Vegas · US

Funding

Constructing inhibitory synapsesR01NS051195 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI MOSS, STEPHEN J · 2006 to 2014
$3.2M
Novel actions of neurosteroids on GABA (A) receptor traffickingR01MH097446 · NIMH · TUFTS UNIVERSITY BOSTON · PI DAVIES, PAUL ANDREW, MOSS, STEPHEN J · 2013 to 2017
$2.1M
Novel actions of neurosteroids on GABA (A) receptor traffickingR01NS108378 · NINDS · TUFTS UNIVERSITY BOSTON · PI DAVIES, PAUL ANDREW, MOSS, STEPHEN J · 2018 to 2022
$2.0M
Deficits in KCC2 activity and the pathophysiology of Status EpilepticusR01NS087662 · NINDS · TUFTS UNIVERSITY BOSTON · PI MOSS, STEPHEN J · 2014 to 2018
$2.0M
Impaired KCC2 function underlies pharmacoresistant seizuresR21NS080064 · NINDS · TUFTS UNIVERSITY BOSTON · PI MOSS, STEPHEN J · 2013 to 2014
$452k
Sensory Hypersensitivity in Fragile X Syndrome Due to Deficits in Tonic Inhibition Reversed by Neuroactive SteroidsR21NS111064 · NINDS · TUFTS UNIVERSITY BOSTON · PI DAVIES, PAUL ANDREW · 2020 to 2021
$450k
NIMH NIH HHS R01 MH097446NINDS NIH HHS R01 NS051195NINDS NIH HHS R01 NS087662NINDS NIH HHS R01 NS108378NINDS NIH HHS R21 NS080064NINDS NIH HHS R21 NS111064
6 · The paper itself

Abstract

The fidelity of inhibitory neurotransmission is dependent on the accumulation of γ-aminobutyric acid type A receptors (GABA

Indexed as

Amino Acid MotifsAnimalsAxonsCells, CulturedGABAergic NeuronsMembrane ProteinsMiceMice, KnockoutReceptors, GABA-ARho Guanine Nucleotide Exchange FactorsSeizuresSynapsesSynaptic TransmissionArhgef9 protein, mouseGabra2 protein, mousegephyrinMembrane ProteinsReceptors, GABA-ARho Guanine Nucleotide Exchange Factorsaxon initial segmentcollybistinepilepsyGABA(A) receptorgephyrininhibition

Identifiers

PMID31315046
PMCPMC8283774
OpenAlexW2962631715

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.