Evidence map›Paper›PMID 31315043›Full record

ArticleCell reports2019

Spinal Neuropeptide Y1 Receptor-Expressing Neurons Form an Essential Excitatory Pathway for Mechanical Itch.

David Acton, Xiangyu Ren, Stefania Di Costanzo, Antoine Dalet, Steeve Bourane, Ilaria Bertocchi, Carola Eva, Martyn Goulding

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
10.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 106 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Central neural circuits underlying itch sensation.Nature reviews. Neuroscience · 2025
    Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Sensory Feedback and the Dynamic Control of Movement.Annual review of neuroscience · 2025
    Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

David ActonMolecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Xiangyu RenMolecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA; Biology Graduate Program, Division of Biological Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Stefania Di CostanzoMolecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA; Biology Graduate Program, Division of Biological Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Antoine DaletMolecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Steeve BouraneMolecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Ilaria BertocchiDepartment of Neuroscience, University of Torino, Neuroscience Institute of the Cavalieri-Ottolenghi Foundation, Regione Gonzole 1, 10043 Orbassano, Italy.
Carola EvaDepartment of Neuroscience, University of Torino, Neuroscience Institute of the Cavalieri-Ottolenghi Foundation, Regione Gonzole 1, 10043 Orbassano, Italy.
Martyn GouldingMolecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: goulding@salk.edu.
Salk Institute for Biological Studies · USNeuroscience Institute · ITUniversity of California, San Diego · US

Funding

Spinal circuits for mechanical itch and light touchR35NS111643 · NINDS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Martyn D Goulding · 2019 to 2026
$9.7M
Intersectional genetic dissection of spinal circuits processing pain and itchR01NS086372 · NINDS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI GOULDING, MARTYN D, MA, QIUFU · 2013 to 2017
$3.5M
Spinal circuits for mechanical itch and light touchR01NS080586 · NINDS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI GOULDING, MARTYN D · 2013 to 2018
$2.8M
NINDS NIH HHS R01 NS080586NINDS NIH HHS R01 NS086372NINDS NIH HHS R35 NS111643
6 · The paper itself

Abstract

Acute itch can be generated by either chemical or mechanical stimuli, which activate separate pathways in the periphery and spinal cord. While substantial progress has been made in mapping the transmission pathway for chemical itch, the central pathway for mechanical itch remains obscure. Using complementary genetic and pharmacological manipulations, we show that excitatory neurons marked by the expression of the neuropeptide Y1 receptor (Y1

Indexed as

AnimalsCapsaicinClozapineInterneuronsMechanoreceptorsMiceMice, KnockoutNeuropeptide YPosterior Horn CellsReceptors, Neuropeptide YReflexSensory System AgentsSpinal CordStimulation, ChemicalCapsaicinClozapineclozapine N-oxideNeuropeptide Yneuropeptide Y-Y1 receptorReceptors, Neuropeptide YSensory System Agentschemical itchdorsal spinal cordinhibitionmechanical itch transmissionneuropeptide YNPY1R signalingpainsomatosensory processingtouchY1 excitatory neurons

Identifiers

PMID31315043
PMCPMC6709688
OpenAlexW2961169698

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.