The Inflammasome: More Than a Protective Innate Immune Mechanism.

Bilyana Stoilova, Paresh Vyas

Open access · bronzeAbstract readComment

In one paragraph

Article in Immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it

0cells of the map it votes in

4citing papers in PubMed

0.4field-weighted citation impact, top 38% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

Role of Inflammasomes in Keloids and Hypertrophic Scars-Lessons Learned from Chronic Diabetic Wounds and Skin Fibrosis.International journal of molecular sciences · 2022
Review
The Crucial Role of NLRP3 Inflammasome in Viral Infection-Associated Fibrosing Interstitial Lung Diseases.International journal of molecular sciences · 2021
Review
Inflammasomes and the Maintenance of Hematopoietic Homeostasis: New Perspectives and Opportunities.Molecules (Basel, Switzerland) · 2021
Review
Zebrafish in Inflammasome Research.Cells · 2019
Review

4 · The record

Corrections and comments

Comment on
Inflammasome Regulates Hematopoiesis through Cleavage of the Master Erythroid Transcription Factor GATA1.2019

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Bilyana StoilovaMRC MHU, BRC Haematology Theme, Oxford Biomedical Research Centre, Oxford Centre for Haematology, WIMM, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

Paresh VyasMRC MHU, BRC Haematology Theme, Oxford Biomedical Research Centre, Oxford Centre for Haematology, WIMM, Radcliffe Department of Medicine, University of Oxford, Oxford, UK; Department of Haematology, Oxford University Hospitals NHS Trust, Oxford, UK. Electronic address: paresh.vyas@imm.ox.ac.uk.

University of Oxford · GB

Funding

Department of Health OXFBRC-2012-1Medical Research Council G1000729Medical Research Council G1000729/94931Medical Research Council MC_U137961146Medical Research Council MC_UU_00016/11Medical Research Council MC_UU_12009/11Medical Research Council MR/L008963/1

6 · The paper itself

Abstract

Little is known about the inflammasome beyond its function in innate immune response. In this issue of Immunity, Tyrkalska et al. report that the inflammasome regulates the balance between erythroid and myeloid differentiation in model systems, providing insights into hematopoietic lineage bias associated with inflammatory conditions.

Indexed as

GATA1 Transcription FactorInflammasomesHematopoiesisImmunity, InnateNLR Family, Pyrin Domain-Containing 3 ProteinGATA1 Transcription FactorInflammasomesNLR Family, Pyrin Domain-Containing 3 Protein

Identifiers

PMID31315035

DOI10.1016/j.immuni.2019.06.022

OpenAlexW2957543275

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.