ArticleImmunity2019
Gata6
Open access · bronzeAbstract read
In one paragraph
Article in Immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers.
0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed
13.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
110 citing papers in PubMed, 173 citations in OpenAlex.
- Human pericardial macrophages suppress cardiac fibrosis through cystatin C signaling after myocardial infarction.JCI insight · 2026Article
- Two differentiation pathways generate large peritoneal macrophages with one replenishing mesothelial border macrophages.Science immunology · 2026Article
- GATA6 marks fibrosis-associated stromal cells rather than repair macrophages in kidney disease.Scientific reports · 2026Article
- The impact of pericardial disruption on heart function and remodeling after myocardial infarction in mice.The international journal of cardiovascular imaging · 2026Article
- Peritoneal macrophages regulate distal wound healing via endocrine release of plasma fibronectin.The Journal of clinical investigation · 2026Article
- E3 ubiquitin ligase TRIM21-mediated K48-linked ubiquitination of ALDH2 rs671 mutant promotes adverse cardiac remodeling.JCI insight · 2026Article
- Structural immunity: immune cells as architects of tissue barriers.Nature reviews. Immunology · 2026Review
- Peritoneal cavity-derived GATA6Journal of advanced research · 2026Article
- Cardiac Macrophages and Fibroblasts Modulate Atrial Fibrillation Maintenance.Circulation research · 2026Article
- Decoding organ fibrosis: mechanistic insights and emerging therapeutic strategies.Signal transduction and targeted therapy · 2026Review
- Tissue-resident macrophage survival depends on mitochondrial function regulated by SerpinB2 in chronic inflammation.Nature communications · 2026Article
- Pleural cavity macrophages promote lung tumor establishment through tissue invasion.Protein & cell · 2026Article
- DNA-damaging chemotherapy reshapes cardiac-resident macrophage composition and function.Science immunology · 2026Article
- Cardiac resident macrophages: the emerging role in arrhythmogenesis.Frontiers in immunology · 2026Review
- Analysis of Intracellular Trafficking of Cholera Toxin B Subunits Depending on Ganglioside GM1 in Tissue-Resident Macrophages.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Large Peritoneal Macrophages Promote the Resolution of Inflammation in Injured Endometrium.Inflammation · 2025Article
- Pattern of Regulatory T Cells, Resident Memory T Cells, and Exhausted T Cells in Human Pericardial Fluid Samples of Cardiovascular Patients.International journal of molecular sciences · 2025Article
- Liver macrophages: development, dynamics, and functions.Cellular & molecular immunology · 2025Review
- The pericardium forms as a distinct structure during heart formation.Nature communications · 2025Article
- Review
50 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
17 authors at 5 institutions in 3 countries.
Justin F DenisetDepartment of Physiology and Pharmacology, University of Calgary, Calgary, AB, T2N 1N4, Canada; Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB, T2N 1N4, Canada.
Darrell BelkeSection of Cardiac Surgery, Department of Cardiac Sciences, Cumming School of Medicine, University of Calgary, Libin Cardiovascular Institute of Alberta, Calgary, AB, T2N 1N4, Canada.
Woo-Yong LeeDepartment of Physiology and Pharmacology, University of Calgary, Calgary, AB, T2N 1N4, Canada; Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB, T2N 1N4, Canada.
Selina K JorchDepartment of Physiology and Pharmacology, University of Calgary, Calgary, AB, T2N 1N4, Canada; Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB, T2N 1N4, Canada.
Carsten DeppermannDepartment of Physiology and Pharmacology, University of Calgary, Calgary, AB, T2N 1N4, Canada; Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB, T2N 1N4, Canada.
Ali Fatehi HassanabadSection of Cardiac Surgery, Department of Cardiac Sciences, Cumming School of Medicine, University of Calgary, Libin Cardiovascular Institute of Alberta, Calgary, AB, T2N 1N4, Canada.
Jeannine D TurnbullSection of Cardiac Surgery, Department of Cardiac Sciences, Cumming School of Medicine, University of Calgary, Libin Cardiovascular Institute of Alberta, Calgary, AB, T2N 1N4, Canada.
Guoqi TengSection of Cardiac Surgery, Department of Cardiac Sciences, Cumming School of Medicine, University of Calgary, Libin Cardiovascular Institute of Alberta, Calgary, AB, T2N 1N4, Canada.
Isaiah RozichMolecular Immunology and Inflammation Branch, NIAMS, NIH, Rockville, MD 20892, USA.
Kelly HudspethMolecular Immunology and Inflammation Branch, NIAMS, NIH, Rockville, MD 20892, USA.
Yuka KannoMolecular Immunology and Inflammation Branch, NIAMS, NIH, Rockville, MD 20892, USA.
Stephen R BrooksBiodata Mining and Discovery Section, NIAMS, Rockville, MD, 20892, USA.
Anna-Katerina HadjantonakisDevelopmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
John J O'SheaMolecular Immunology and Inflammation Branch, NIAMS, NIH, Rockville, MD 20892, USA.
Georg F WeberDepartment of Surgery, Universitätsklinikum Erlangen, Friedrich-Alexander Universität, Erlangen-Nürnberg, 91054, Germany.
Paul W M FedakSection of Cardiac Surgery, Department of Cardiac Sciences, Cumming School of Medicine, University of Calgary, Libin Cardiovascular Institute of Alberta, Calgary, AB, T2N 1N4, Canada.
Paul KubesDepartment of Physiology and Pharmacology, University of Calgary, Calgary, AB, T2N 1N4, Canada; Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, AB, T2N 1N4, Canada; Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB, T2N 1N4, Canada. Electronic address: pkubes@ucalgary.ca.
Libin Cardiovascular Institute of Alberta · CAUniversity of Calgary · CANational Institute of Arthritis and Musculoskeletal and Skin Diseases · USFriedrich-Alexander-Universität Erlangen-Nürnberg · DEMemorial Sloan Kettering Cancer Center · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4MStat transcription factors in immunoregulation and autoimmune diseaseZIAAR041159 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI O'SHEA, JOHN · 2009 to 2025
$49.3MHigh Throughput Next Generation Sequencing: supports genomics and epigenomics research in muscle, skin, bone and autoimmune diseases.ZICAR041207 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI DELL'ORSO, STEFANIA · 2016 to 2025
$12.3MApplying Bioinformatics to Research in Immune, Muscle, and Bone DiseasesZIHAR041173 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI GADINA, MASSIMO · 2009 to 2020
$11.0MMorphogenesis of mammalian gut endodermR01DK084391 · NIDDK · SLOAN-KETTERING INST CAN RESEARCH · PI HADJANTONAKIS, ANNA-KATERINA · 2009 to 2018
$4.1MCIHRNCI NIH HHS P30 CA008748NIDDK NIH HHS R01 DK084391
Abstract
Macrophages play an important role in structural cardiac remodeling and the transition to heart failure following myocardial infarction (MI). Previous research has focused on the impact of blood-derived monocytes on cardiac repair. Here we examined the contribution of resident cavity macrophages located in the pericardial space adjacent to the site of injury. We found that disruption of the pericardial cavity accelerated maladaptive post-MI cardiac remodeling. Gata6
Indexed as
AnimalsCell MovementCells, CulturedFibrosisGATA6 Transcription FactorHeartHumansMacrophagesMiceMice, Inbred C57BLMice, TransgenicMyocardial InfarctionMyocardiumPericardiumVentricular RemodelingGata6 protein, mouseGATA6 Transcription Factorfibrosismyocardial infarctionPericardial macrophage
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.