ArticleJournal of dental research2019
Risk of Adverse Reactions to Oral Antibiotics Prescribed by Dentists.
Article in Journal of dental research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults.The Cochrane database of systematic reviews · 2024Pooled it
- Antibiotics to prevent complications following tooth extractions.The Cochrane database of systematic reviews · 2021Pooled it
- Article
- Antibiotic Prophylaxis of Infective Endocarditis in Dentistry: An Update on the ESC, AHA, and NICE Guidelines.Journal of clinical medicine · 2026Review
- Ten-year trends in antimicrobial and analgesic prescribing by NHS dentists in England: a retrospective analysis study.British dental journal · 2026Article
- Trends in adverse drug reaction reporting by dentists: a 15-year analysis of German pharmacovigilance data.Clinical oral investigations · 2026Article
- A Thorough Analysis of Changing Antibiotic Resistance in Dental Practice: A Narrative Review.Cureus · 2026Review
- 2023 European Society of Cardiology guidelines for the management of infective endocarditis : Statement of endorsement by the NVVC Full version.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2026Review
- Article
- Common Medications Prescribed by Oral Medicine Practitioners in Saudi Arabia: A Cross-Sectional Study.Journal of multidisciplinary healthcare · 2026Article
- Costs-Outcome Description Arising From Side Effects due the Over-Prescription of Antibiotics in Oral Healthcare in Chile.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2025Article
- Unveiling Drug-Drug Interactions in Dental Patients: A Retrospective Real-World Study.Dentistry journal · 2025Article
- Clinical effectiveness of aloe vera gel as an adjunct to mechanical debridement in patients with periodontitis: A systematic review and meta-analysis.Journal of advanced periodontology & implant dentistry · 2025Article
- Pharmacovigilance Strategies to Address Resistance to Antibiotics and Inappropriate Use-A Narrative Review.Antibiotics (Basel, Switzerland) · 2024Review
- Frequency and Risk Factor Analysis for Metronidazole-Associated Neurologic Adverse Events.Journal of general internal medicine · 2024Article
- Targeted Clindamycin Delivery Systems: Promising Options for Preventing and Treating Bacterial Infections Using Biomaterials.International journal of molecular sciences · 2024Review
- Is Antibiotic Prophylaxis Needed for the Extraction of Premolars for Orthodontic Purposes?Cureus · 2024Article
- Assessment of Knowledge, Attitude, and Practice of Pharmacovigilance and Materiovigilance among Oral Health Practitioners in India.Journal of pharmacy & bioallied sciences · 2024Article
- Alternatives to β-Lactams as Agents for the Management of Dentoalveolar Abscess.Current topics in medicinal chemistry · 2024Review
- Implementation of an Enhanced Recovery After Surgical Endoscopy protocol to improve outcomes following endoscopic sleeve gastroplasty.iGIE : innovation, investigation and insights · 2023Article
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
Dentists prescribe a large portion of all oral antibiotics, and these are associated with a risk of adverse drug reactions (ADRs). The aim of this study was to quantify the risk of ADRs associated with oral antibiotics commonly prescribed by dentists. NHS Digital Prescribing data and Yellow Card Drug Analysis data for 2010 to 2017 were abstracted to quantify dental antibiotic prescribing in England, and the rate and types of ADRs associated with them. During the period of study, the mean number of actively practicing dentists in England was 23,624. Amoxicillin accounted for 64.8% of dental antibiotic prescribing and had the lowest reported rate of fatal ADRs (0.1/million prescriptions) and overall ADRs (21.5/million prescriptions). Indeed, amoxicillin was respectively 6 and 3 times less likely to cause an ADR than the other penicillins, penicillin V and amoxicillin + clavulanic acid, and appears to be very safe in patients with no history of penicillin allergy. In contrast, clindamycin, which is often used in patients with penicillin allergy, had the highest rate of fatal (2.9/million prescriptions) and overall (337.3/million prescriptions) ADRs, with
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.