Evidence map›Paper›PMID 31314997›Full record

ArticleAnnals of the American Thoracic Society2019

Fulvestrant for the Treatment of Pulmonary Arterial Hypertension.

Steven M Kawut, Diane Pinder, Nadine Al-Naamani, Amber McCormick, Harold I Palevsky, Jason Fritz, K Akaya Smith, Jeremy A Mazurek, Margaret F Doyle, Margaret R MacLean and 2 more

Registry-linked trialOpen access · greenAbstract readLetter
In one paragraph

Article in Annals of the American Thoracic Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02911844 (Estrogen Receptor Antagonist in Patients With Pulmonary Arterial Hypertension), which is not on this map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02911844 phase2completednot on this map

Estrogen Receptor Antagonist in Patients With Pulmonary Arterial Hypertension

TypeinterventionalSponsorUniversity of PennsylvaniaRan2017 to 2018Enrolled5ConditionsPulmonary Arterial HypertensionArmsFulvestrant
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Management of pulmonary arterial hypertension in systemic sclerosis: from classical treatments to new horizons.European respiratory review : an official journal of the European Respiratory Society · 2026
    Pooled it
  2. A Systematic Review of Novel Therapies of Pulmonary Arterial Hypertension.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2024
    Pooled it
  3. Review
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  12. Sex and gender in pulmonary arterial hypertension.European respiratory review : an official journal of the European Respiratory Society · 2021
    Review
  13. Insights from the Menstrual Cycle in Pulmonary Arterial Hypertension.Annals of the American Thoracic Society · 2021
    Observational
  14. Review
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Steven M KawutPerelman School of Medicine at the University of PennsylvaniaPhiladelphia, Pennsylvania.
Diane PinderPerelman School of Medicine at the University of PennsylvaniaPhiladelphia, Pennsylvania.
Nadine Al-NaamaniPerelman School of Medicine at the University of PennsylvaniaPhiladelphia, Pennsylvania.
Amber McCormickPerelman School of Medicine at the University of PennsylvaniaPhiladelphia, Pennsylvania.
Harold I PalevskyPerelman School of Medicine at the University of PennsylvaniaPhiladelphia, Pennsylvania.
Jason FritzPerelman School of Medicine at the University of PennsylvaniaPhiladelphia, Pennsylvania.
K Akaya SmithPerelman School of Medicine at the University of PennsylvaniaPhiladelphia, Pennsylvania.
Jeremy A MazurekPerelman School of Medicine at the University of PennsylvaniaPhiladelphia, Pennsylvania.
Margaret F DoyleUniversity of VermontBurlington, Vermontand.
Margaret R MacLeanUniversity of StrathclydeGlasgow, United Kingdom.
Angela DeMichelePerelman School of Medicine at the University of PennsylvaniaPhiladelphia, Pennsylvania.
David A MankoffPerelman School of Medicine at the University of PennsylvaniaPhiladelphia, Pennsylvania.
University of Pennsylvania · USUniversity of Strathclyde · GBUniversity of Vermont · US

Funding

Phenotypic Diversity in COVID-19UL1TR001878 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2016 to 2025
$102.4M
Estrogen signaling in portopulmonary hypertensionR01HL113988 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI FALLON, MICHAEL TODD, KAWUT, STEVEN M · 2012 to 2016
$3.8M
Mentored Patient-Oriented Research in Pulmonary Arterial HypertensionK24HL103844 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KAWUT, STEVEN M · 2011 to 2020
$1.6M
Obesity in Pulmonary Arterial HypertensionK23HL141584 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI AL-NAAMANI, NADINE · 2018 to 2022
$970k
Biotechnology and Biological Sciences Research Council BB/N503691/1British Heart Foundation RE/13/5/30177British Heart Foundation RG/16/2/32153NCATS NIH HHS UL1 TR001878NHLBI NIH HHS K23 HL141584NHLBI NIH HHS K24 HL103844NHLBI NIH HHS R01 HL113988
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AgedEstrogen Receptor AntagonistsFemaleFulvestrantHumansInjections, IntramuscularMiddle AgedPilot ProjectsPostmenopauseProof of Concept StudyPulmonary Arterial HypertensionTreatment OutcomeEstrogen Receptor AntagonistsFulvestrant

Identifiers

PMID31314997
PMCPMC6945473
OpenAlexW2957605551

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.