SynthesisThe Journal of infectious diseases2020
Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1N1) Virus Infection.
Open access · bronzeAbstract readMeta-Analysis
In one paragraph
Synthesis in The Journal of infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
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21citing papers in PubMed, 2 pooled it
2.6field-weighted citation impact, top 10% of its field
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Working group summary of the 2023 full update of the Finnish national guidelines for paediatric lower respiratory tract infections.Acta paediatrica (Oslo, Norway : 1992) · 2025Guideline
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- Influenza and Aging: Clinical Manifestations, Complications, and Treatment Approaches in Older Adults.Drugs & aging · 2025Review
- Respiratory viruses associated with severe acute respiratory infection in children aged <5 years at a tertiary care hospital in Delhi, India during 2013-15.Journal of global health · 2024Article
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- Incidence of laboratory-confirmed influenza and RSV and associated presenteeism and absenteeism among healthcare personnel, Israel, influenza seasons 2016 to 2019.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2024Article
- Influenza A infections: predictors of disease severity.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Incidence of respiratory virus illness and hospitalizations in a Panama and El Salvador birth cohort, 2014-2018.Lancet regional health. Americas · 2022Article
- Influenza.Lancet (London, England) · 2022Review
- Point-of-Care Influenza Testing Impacts Clinical Decision, Patient Flow, and Length of Stay in Hospitalized Adults.The Journal of infectious diseases · 2022Observational
- A literature review of severity scores for adults with influenza or community-acquired pneumonia - implications for influenza vaccines and therapeutics.Human vaccines & immunotherapeutics · 2021Review
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Corrections and comments
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Authors and funding
71 authors at 20 institutions in 38 countries.
Sudhir VenkatesanDivision of Epidemiology and Public Health, University of Nottingham, Nottingham.
Puja R MylesDivision of Epidemiology and Public Health, University of Nottingham, Nottingham.
Kirsty J BoltonSchool of Mathematical Sciences, University of Nottingham, Nottingham.
Stella G MuthuriMRC Unit for Lifelong Health and Ageing, University College London.
Tarig Al KhuwaitirDepartment of Medicine, King Saud Medical City, Riyadh, Kingdom of Saudi Arabia.
Ashish P AnovadiyaDepartment of Pharmacology, Government Medical College and Sir Takhtasinhji General Hospital, Bhavnagar, India.
Eduardo Azziz-BaumgartnerInfluenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
Tahar BajjouUniversity Mohammed V-Souissi, Faculty of Medicine and Pharmacy, Mohammed V Military Teaching Hospital, Biosafety Level 3 and Research Laboratory, Rabat, Morocco.
Matteo BassettiSanta Maria Misericordia Hospital, Udine.
Bojana BeovicDepartment of Infectious Diseases, University Medical Center, Ljubljana.
Barbara BertischInstitute of Global Health, University of Geneva, Switzerland.
Isabelle BonmarinInstitut de Veille Sanitaire, Saint Maurice, France.
Robert BooyNational Centre for Immunisation Research and Surveillance, Children's Hospital at Westmead, University of Sydney.
Victor H Borja-AburtoInstituto Mexicano del Seguro Social.
Heinz BurgmannMedical University of Vienna, Austria.
Bin CaoBeijing Chao-Yang Hospital, Capital Medical University.
Jordi CarratalaDepartment of Infectious Diseases, Bellvitge University Hospital, Bellvitge Biomedical Research Institute, Spanish Network for Research in Infectious Diseases.
Tserendorj ChinbayarNational Influenza Center, National Center of Communicable Diseases, Ministry of Health, Ulaanbaatar, Mongolia.
Catia CillonizHospital Clinic, August Pi I Sunyer Biomedical Research Institute, University of Barcelona, CIBERES, Barcelona.
Justin T DenholmVictorian Infectious Diseases Service and Department of Microbiology and Immunology, at the Peter Doherty Institute for Infection and Immunity, Parkville.
Samuel R DominguezDepartment of Pediatric Infectious Diseases, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora.
Pericles A D DuarteUniversidade Estadual do Oeste do Paraná-UNIOESTE, Cascavel.
Gal Dubnov-RazEdmond and Lily Safra Children's Hospital, Sheba Medical Center, Ramat Gan.
Sergio FanellaSection of Pediatric Infectious Diseases, University of Manitoba, Winnipeg.
Zhancheng GaoDepartment of Respiratory and Critical Care Medicine, Peking University People's Hospital.
Patrick GérardinPôle Femme Mère Enfant.
Maddalena GiannellaDepartment of Clinical and Surgical Sciences, Sant'Orsola Malpighi Hospital, University of Bologna, Bologna, Italy.
Sophie GubbelsDepartment of Infectious Disease Epidemiology, Sector for National Health Documentation and Research, Statens Serum Institut, Copenhagen, Denmark.
Jethro HerbergSection of Paediatrics, Division of Infectious Disease, Imperial College, London.
Anjarath Lorena Higuera IglesiasDepartment of Research in Clinical Epidemiology, Instituto Nacional de Enfermedades Respiratorias Dr. Ismael Cosío Villegas, Mexico City, Mexico.
Peter H HoegerCatholic Children's Hospital Wilhelmstift, Hamburg.
Xiao Yun HuPeking Union Medical College Hospital, Beijing.
Quazi T IslamDhaka Medical College Hospital, Bangladesh.
Mirela F JiménezDepartamento de Ginecologia e Obstetrícia-UFCSPA, Preceptora da Residência Médica do Hospital Fêmina, Fêmina, Brazil.
Gerben KeijzersGold Coast University Hospital, Gold Coast, Australia.
Hossein KhaliliDepartment of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Gabriela KusznierzNational Institute of Respiratory Diseases "Emilio Coni" ANLIS "C. Malbran," Santa Fe.
Ilija KuzmanUniversity Hospital for Infectious Diseases, University of Zagreb School of Medicine, Croatia.
Eduard LangeneggerDepartment of Obstetrics and Gynaecology, Stellenbosch University-Tygerberg, Cape Town, South Africa.
Kamran B LankaraniHealth Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Yee-Sin LeoDepartment of Infectious Diseases, Tan Tock Seng Hospital.
Romina P LibsterDepartment of Pediatrics, Vanderbilt University, Nashville, Tennessee.
Rita LinkoHelsinki University Hospital, Finland.
Faris MadanatDepartment of Pediatrics, King Hussein Cancer Center, Amman, Jordan.
Efstratios MaltezosUnit of Infectious Diseases, University General Hospital of Alexandroupolis, Democritus University Thrace, Dragana.
Abdullah MamunBritish Columbia Centre for Disease Control, Vancouver.
Toshie ManabeDepartment of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan.
Gokhan MetanDepartment of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Hacettepe University, Ankara.
Auksė MickieneLithuanian University of Health Sciences, Kaunas, Lithuania.
Dragan MikićMilitary Medical Academy, Clinic for Infectious and Tropical Diseases, University of Defense, Belgrade, Serbia.
Kristin G I MohnInfluenza Center, Department of Clinical Science, University of Bergen.
Maria E OlivaDepartment of Infection Control, Hospital San Martín de Paraná, Entre Ríos, Argentina.
Mehpare OzkanPediatric Neurology Department, Bahçeşehir University.
Dhruv ParekhRespiratory and Critical Care Medicine, Institute of Inflammation and Ageing, University of Birmingham, Birmingham.
Mical PaulDivision of Infectious Diseases, Rambam Health Care Campus, Haifa, Israel.
Barbara A RathDepartment of Pediatrics, Charité-University Medical Center Berlin, Berlin, Germany.
Samir RefaeyEpidemiology and Surveillance Department, Ministry of Health and Population, Cairo, Egypt.
Alejandro H RodríguezCritical Care Department, Hospital Joan XXIII, IISPV-URV-CIBERES, Tarragona, Spain.
Bunyamin SertogullarindanDepartment of Pulmonary Medicine, Medical Faculty, Yuzuncu Yil University, Van, Turkey.
Joanna Skręt-MagierłoUniwersytet Rzeszowski, Rzeszow.
Ayper SomerDepartment of Pediatric Infectious Diseases, Istanbul Medical Faculty, Istanbul University, Istanbul.
Ewa TalarekDepartment of Children's Infectious Diseases, Medical University of Warsaw, Warsaw, Poland.
Julian W TangDepartment of Respiratory Sciences, University of Leicester.
Kelvin ToCarol Yu Centre for Infection and Division of Infectious Diseases, Department of Microbiology, Queen Mary Hospital, University of Hong Kong, Hong Kong Special Administrative Region, China.
Dat TranAcute and Communicable Disease Prevention, Public Health Division, Oregon Health Authority, Portland.
Timothy M UyekiInfluenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
Wendy VaudryDivision of Infectious Diseases, Department of Pediatrics, University of Alberta, Stollery Children's Hospital, Edmonton, Canada.
Tjasa VidmarGeneral Hospital Slovenj Gradec, Slovenj Gradec, Slovenia.
Paul ZarogoulidisPulmonary Department, "G. Papanikalaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
PRIDE Consortium Investigators
Jonathan S Nguyen-Van-TamDivision of Epidemiology and Public Health, University of Nottingham, Nottingham.
University of Nottingham · GBAristotle University of Thessaloniki · GRChinese Academy of Medical Sciences & Peking Union Medical College · CNBC Centre for Disease Control · CACenters for Disease Control and Prevention · USPeking University · CNShiraz University of Medical Sciences · IRVan Yüzüncü Yıl Üniversitesi · TRAdministración Nacional de Laboratorios e Institutos de Salud · ARBahçeşehir University · TRBellvitge University Hospital · ESCapital Medical University · CNCentro de Investigación Biomédica en Red de Enfermedades Respiratorias · ESCharité - Universitätsmedizin Berlin · DEChildren's Hospital at Westmead · AUChildren's Hospital Colorado · USConsejo Nacional de Investigaciones Científicas y Técnicas · ARDemocritus University of Thrace · GRDhaka Medical College and Hospital · BDGold Coast Hospital · AU
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe effect of neuraminidase inhibitor (NAI) treatment on length of stay (LoS) in patients hospitalized with influenza is unclear.
methodsWe conducted a one-stage individual participant data (IPD) meta-analysis exploring the association between NAI treatment and LoS in patients hospitalized with 2009 influenza A(H1N1) virus (A[H1N1]pdm09) infection. Using mixed-effects negative binomial regression and adjusting for the propensity to receive NAI, antibiotic, and corticosteroid treatment, we calculated incidence rate ratios (IRRs) and 95% confidence intervals (CIs). Patients with a LoS of <1 day and those who died while hospitalized were excluded.
resultsWe analyzed data on 18 309 patients from 70 clinical centers. After adjustment, NAI treatment initiated at hospitalization was associated with a 19% reduction in the LoS among patients with clinically suspected or laboratory-confirmed influenza A(H1N1)pdm09 infection (IRR, 0.81; 95% CI, .78-.85), compared with later or no initiation of NAI treatment. Similar statistically significant associations were seen in all clinical subgroups. NAI treatment (at any time), compared with no NAI treatment, and NAI treatment initiated <2 days after symptom onset, compared with later or no initiation of NAI treatment, showed mixed patterns of association with the LoS.
conclusionsWhen patients hospitalized with influenza are treated with NAIs, treatment initiated on admission, regardless of time since symptom onset, is associated with a reduced LoS, compared with later or no initiation of treatment.
Indexed as
Influenza A Virus, H1N1 SubtypeLength of StayPandemicsAdolescentAdrenal Cortex HormonesAdultAgedAnti-Bacterial AgentsAntiviral AgentsChildEnzyme InhibitorsFemaleHumansInfluenza, HumanMaleMiddle AgedAdrenal Cortex HormonesAnti-Bacterial AgentsAntiviral AgentsEnzyme InhibitorsNeuraminidaseantiviralsIPD meta-analysislength of stayNeuraminidase inhibitorspandemic influenza
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