ArticleInflammatory bowel diseases2020
Opportunistic Infections Are More Prevalent in Crohn's Disease and Ulcerative Colitis: A Large Population-Based Study.
Article in Inflammatory bowel diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 34 citations in OpenAlex.
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- Cytomegalovirus Colitis Mimicking Ulcerative Colitis Flare in an Immunocompromised Patient: A Challenging Diagnosis.Cureus · 2024Article
- Dual-targeted treatment for inflammatory bowel disease: Whether fecal microbiota transplantation can be an important part of it.World journal of gastroenterology · 2024Article
- Increasing ratio of opportunistic infections associated with sunshine exposure and economic level burdening Chinese inflammatory bowel disease hospitalized patients: the first nationwide survey from 2014 to 2019.BMC public health · 2024Article
- Evidence-based pathogenesis and treatment of ulcerative colitis: A causal role for colonic epithelial hydrogen peroxide.World journal of gastroenterology · 2022Review
- Impact of the Coronavirus Disease Pandemic on Health-Related Quality of Life of Patients with Inflammatory Bowel Disease.Digestive diseases and sciences · 2022Article
- Association Between Portal Vein Thrombosis and Pouchitis in Patients with Ulcerative Colitis.Digestive diseases and sciences · 2022Article
- Development of Inflammatory Bowel Disease in HIV Patients: A Danish Cohort Study (1983-2018) With American Validation (1999-2018).Gastro hep advances · 2022Article
- Recurrence of Clostridium Difficile and Cytomegalovirus Infections in Patients with Ulcerative Colitis Who Undergo Ileal Pouch-Anal Anastomosis.Digestive diseases and sciences · 2021Article
- Rising Inflammatory Bowel Disease Prevalence Highlights the Need for Effective, Cost-Effective Therapies.Inflammatory bowel diseases · 2020Article
- Cytomegalovirus Infection Exacerbates Experimental Colitis by Promoting IL-23 Production.Inflammation · 2020Article
- Quantifying Risk Factors for Atrial Fibrillation: Retrospective Review of a Large Electronic Patient Database.Journal of atrial fibrillationArticle
- Vagus Nerve Stimulation and Sacral Nerve Stimulation for Inflammatory Bowel Disease: A Systematic Review.Journal of translational gastroenterologyArticle
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8 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundOpportunistic infections (OIs) are more common in patients with inflammatory bowel disease (IBD); however, there have been limited large-scale studies of OIs in IBD. We investigated the epidemiological characteristics of OI in Crohn's disease (CD) and ulcerative colitis (UC) using a large population-based database.
methodsData were collected from a commercial database (Explorys Inc., Cleveland, OH, USA) that provided electronic health records from 26 major integrated US health care systems from 1999 to March 2018. In this data set, we identified all CD and UC patients, based on Systemized Nomenclature of Medicine-Clinical Terms. Within these cohorts, we identified a variety of OIs and compared the prevalence rate of OI in individuals with IBD with that of controls (patients in the database between March 2013 and March 2018 without the diagnosis of IBD).
resultsExplorys included 153,290 patients with CD and 128,540 patients with UC between March 2013 and March 2018. The prevalence of OIs was 17.8% in CD, 19.2% in UC, and 7% in non-IBD controls. When compared with non-IBD controls, all OIs were more common in CD (prevalence ratio [PR], 2.54; 95% confidence interval [CI], 2.51-2.57) and UC (PR, 2.74; 95% CI, 2.71-2.77). Overall, viral infections were numerically more common, whereas bacterial infections had the highest PRs in CD and UC when compared with controls without IBD.
conclusionsWe found significantly higher rates of OI in IBD. Our study suggests the need for close follow-up of IBD patients to diagnose and provide vaccinations where applicable for prevention of infections.
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