Evidence map›Paper›PMID 31314813›Full record

ArticlePloS one2019

MR susceptibility contrast imaging using a 2D simultaneous multi-slice gradient-echo sequence at 7T.

Wei Bian, Adam B Kerr, Eric Tranvinh, Sherveen Parivash, Benjamin Zahneisen, May H Han, Christopher B Lock, Maged Goubran, Kongrong Zhu, Brian K Rutt and 1 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Neuroimaging at 7 Tesla: a pictorial narrative review.Quantitative imaging in medicine and surgery · 2022
    Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Wei BianDepartment of Biomedical Engineering, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Adam B KerrDepartment of Electrical Engineering, Stanford University, Palo Alto, CA, United States of America.
Eric TranvinhDepartment of Radiology, Stanford University, Palo Alto, CA, United States of America.
Sherveen ParivashDepartment of Radiology, Stanford University, Palo Alto, CA, United States of America.
Benjamin ZahneisenDepartment of Radiology, Stanford University, Palo Alto, CA, United States of America.
May H HanDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Palo Alto, CA, United States of America.
Christopher B LockDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Palo Alto, CA, United States of America.
Maged GoubranDepartment of Radiology, Stanford University, Palo Alto, CA, United States of America.
Kongrong ZhuDepartment of Electrical Engineering, Stanford University, Palo Alto, CA, United States of America.
Brian K RuttDepartment of Radiology, Stanford University, Palo Alto, CA, United States of America.
Michael M ZeinehDepartment of Radiology, Stanford University, Palo Alto, CA, United States of America.

Funding

Training and DisseminationP41EB015891 · NIBIB · STANFORD UNIVERSITY · PI GLOVER, GARY H · 2012 to 2019
$10.7M
Iron as an Imaging Biomarker for Inflammation in ADR01AG061120 · NIA · STANFORD UNIVERSITY · PI ZEINEH, MICHAEL M · 2019 to 2023
$3.5M
Next Generation 7T MRI Platform Upgrade with Parallel Transmit CapabilitiesS10RR026351 · NCRR · STANFORD UNIVERSITY · PI RUTT, BRIAN KEITH · 2011 to 2011
$600k
NCRR NIH HHS S10 RR026351NIA NIH HHS R01 AG061120NIBIB NIH HHS P41 EB015891
6 · The paper itself

Abstract

purposeTo develop a 7T simultaneous multi-slice (SMS) 2D gradient-echo sequence for susceptibility contrast imaging, and to compare its quality to 3D imaging.

methodsA frequency modulated and phase cycled RF pulse was designed to simultaneously excite multiple slices in multi-echo 2D gradient-echo imaging. The imaging parameters were chosen to generate images with susceptibility contrast, including T2*-weighted magnitude/phase images, susceptibility-weighted images and quantitative susceptibility/R2* maps. To compare their image quality with 3D gradient-echo imaging, both 2D and 3D imaging were performed on 11 healthy volunteers and 4 patients with multiple sclerosis (MS). The signal to noise ratio (SNR) in gray and white matter and their contrast to noise ratio (CNR) was simulated for the 2D and 3D magnitude images using parameters from the imaging. The experimental SNRs and CNRs were measured in gray/white matter and deep gray matter structures on magnitude, phase, R2* and QSM images from volunteers and the visibility of MS lesions on these images from patients was visually rated. All SNRs and CNRs were compared between the 2D and 3D imaging using a paired t-test.

resultsAlthough the 3D magnitude images still had significantly higher SNRs (by 13.0~17.6%), the 2D magnitude and QSM images generated significantly higher gray/white matter or globus pallidus/putamen contrast (by 13.3~87.5%) and significantly higher MS lesion contrast (by 5.9~17.3%).

conclusion2D SMS gradient-echo imaging can serve as an alternative to often used 3D imaging to obtain susceptibility-contrast-weighted images, with an advantage of providing better image contrast and MS lesion sensitivity.

Indexed as

AdultAlgorithmsBrain MappingContrast MediaFemaleGlobus PallidusGray MatterHumansImage Processing, Computer-AssistedImaging, Three-DimensionalMagnetic Resonance ImagingMaleMiddle AgedPutamenSignal-To-Noise RatioSoftwareContrast Media

Identifiers

PMID31314813
PMCPMC6636815

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.