Evidence map›Paper›PMID 31314797›Full record

ArticlePloS one2019

Prevalence and predictors of polypharmacy prescription among type 2 diabetes patients at a tertiary care department in Ningbo, China: A retrospective database study.

Jialin Li, Kaushik Chattopadhyay, Miao Xu, Yanshu Chen, Fangfang Hu, Xingzhen Wang, Li Li

Abstract read
In one paragraph

Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

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12citing papers in PubMed, 1 pooled it
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Jialin LiDepartment of Endocrinology and Metabolism, Ningbo First Hospital, Ningbo, Zhejiang Province, PR China.
Kaushik ChattopadhyayDivision of Epidemiology and Public Health, School of Medicine, The University of Nottingham, Nottingham, United Kingdom.
Miao XuDepartment of Endocrinology and Metabolism, Ningbo First Hospital, Ningbo, Zhejiang Province, PR China.
Yanshu ChenDepartment of Endocrinology and Metabolism, Ningbo First Hospital, Ningbo, Zhejiang Province, PR China.
Fangfang HuDepartment of Endocrinology and Metabolism, Ningbo First Hospital, Ningbo, Zhejiang Province, PR China.
Xingzhen WangDepartment of Endocrinology and Metabolism, Ningbo First Hospital, Ningbo, Zhejiang Province, PR China.
Li LiDepartment of Endocrinology and Metabolism, Ningbo First Hospital, Ningbo, Zhejiang Province, PR China.ORCID 0000-0001-6301-3544

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo determine the prevalence of polypharmacy prescription among type 2 diabetes (T2DM) patients at a tertiary care department in Ningbo, China, and to determine factors that independently predict this polypharmacy prescription.

methodsA retrospective cross-sectional study was conducted using an existing computerised medical records database. This database was screened from 2012 to 2017 for adult patients with T2DM and parameters like prescribed medicines and socio-demographic, behavioural and other medical information. Polypharmacy prescription was defined as the simultaneous prescription of ≥5 medicines by the clinician at the time of discharge for daily usage by the patient as part of his/her long-term treatment plan.

resultsThe study inclusion criteria were satisfied by 3370 T2DM patients. Over a 5-year period, 72.2% (n = 2432) of T2DM patients were prescribed polypharmacy. On an average, eight medicines were prescribed to them. The odds of polypharmacy prescription increased with patients' age (18-39 years: 1; 40-59 years: OR 1.86, 95% CI 1.28-2.71; and ≥60 years: 2.42, 1.65-3.55), duration of T2DM (≤1 year: 1; >5-10 years: 1.70, 1.10-2.62; and >10 years: 2.55, 1.68-3.89), and length of hospital stay (≤5 days: 1; >5-10 days: 2.43, 1.86-3.17; and >10 days: 2.99, 2.24-3.99), and were higher in those with poor blood glucose level (2.09, 1.67-2.62) and with comorbidities like other endocrine, nutritional and metabolic diseases (2.24, 1.76-2.85), circulatory system diseases (4.35, 3.62-5.23), skin and subcutaneous tissue diseases (1.64, 1.04-2.59), and musculoskeletal system and connective tissue diseases (1.61, 1.27-2.03). The odds of polypharmacy prescription were lower in those with comorbidities like neoplasms (0.51, 0.36-0.70) and during pregnancy, childbirth and the puerperium (0.06, 0.01-0.49).

conclusionsAround three fourth of T2DM patients at the tertiary care department were prescribed polypharmacy, and the predictors were identified. The study findings could be taken into consideration in future interventional studies aimed at supporting medicines optimisation (and deprescribing) among these patients.

Indexed as

PolypharmacyTertiary Care CentersAdolescentAdultChinaCross-Sectional StudiesDatabases, FactualDiabetes Mellitus, Type 2FemaleHumansMaleMiddle AgedOdds RatioPrevalencePublic Health SurveillanceRetrospective Studies

Identifiers

PMID31314797
PMCPMC6636754

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.