Evidence map›Paper›PMID 31314784›Full record

ArticlePLoS pathogens2019

The Edwardsiella piscicida thioredoxin-like protein inhibits ASK1-MAPKs signaling cascades to promote pathogenesis during infection.

Dahai Yang, Xiaohong Liu, Wenting Xu, Zhaoyan Gu, Cuiting Yang, Lingzhi Zhang, Jinchao Tan, Xin Zheng, Zhuang Wang, Shu Quan and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PLoS pathogens, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 22 citations in OpenAlex.

  1. Virulence · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. A Novel Thioredoxin-Like Protein ofFrontiers in cellular and infection microbiology · 2022
    Article
  6. Article
  7. Article
  8. Article
  9. The Translocation and Assembly Module (TAM) ofFrontiers in microbiology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Dahai YangState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
Xiaohong LiuState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
Wenting XuState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
Zhaoyan GuState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
Cuiting YangState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
Lingzhi ZhangState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
Jinchao TanState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
Xin ZhengState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
Zhuang WangState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
Shu QuanState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.ORCID 0000-0002-6672-4947
Yuanxing ZhangState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
Qin LiuState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.ORCID 0000-0002-5465-1189
East China University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is important that bacterium can coordinately deliver several effectors into host cells to disturb the cellular progress during infection, however, the precise role of effectors in host cell cytosol remains to be resolved. In this study, we identified a new bacterial virulence effector from pathogenic Edwardsiella piscicida, which presents conserved crystal structure to thioredoxin family members and is defined as a thioredoxin-like protein (Trxlp). Unlike the classical bacterial thioredoxins, Trxlp can be translocated into host cells, mimicking endogenous thioredoxin to abrogate ASK1 homophilic interaction and phosphorylation, then suppressing the phosphorylation of downstream Erk1/2- and p38-MAPK signaling cascades. Moreover, Trxlp-mediated inhibition of ASK1-Erk/p38-MAPK axis promotes the pathogenesis of E. piscicida in zebrafish larvae infection model. Taken together, these data provide insights into the mechanism underlying the bacterial thioredoxin as a virulence effector in downmodulating the innate immune responses during E. piscicida infection.

Indexed as

Bacterial ProteinsCrystallography, X-RayEdwardsiellaEnterobacteriaceae InfectionsHeLa CellsHost Microbial InteractionsHumansImmunity, InnateMAP Kinase Kinase Kinase 5MAP Kinase Signaling SystemModels, MolecularSignal TransductionThioredoxinsVirulenceVirulence FactorsBacterial ProteinsMAP3K5 protein, humanMAP Kinase Kinase Kinase 5ThioredoxinsVirulence Factors

Identifiers

PMID31314784
PMCPMC6636751
OpenAlexW2962488455

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.