Evidence map›Paper›PMID 31314668›Full record

Trial reportJournal of neurophysiology2019

Field potential 1/

Ashan Veerakumar, Vineet Tiruvadi, Bryan Howell, Allison C Waters, Andrea L Crowell, Bradley Voytek, Patricio Riva-Posse, Lydia Denison, Justin K Rajendra, Johnathan A Edwards and 3 more

Registry-linked trialAbstract readClinical Trial
In one paragraph

Trial report in Journal of neurophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05773755 (Deep Brain Stimulation for Treatment Resistant Depression), which is not on this map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05773755 narecruitingnot on this mapstarted 2023, after this paper: background citation

Deep Brain Stimulation for Treatment Resistant Depression: Exploration of Local Field Potentials (LFPs) With the Medtronic Percept PC System

TypeinterventionalSponsorHelen Mayberg, MDRan2023 to 2028Enrolled20ConditionsMajor Depressive Disorder, Treatment Resistant DepressionArmsMedtronic Percept PC DBS system
3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Electrophysiological features of signals recorded from white matter.bioRxiv : the preprint server for biology · 2026
    Article
  4. Increased Aperiodic Exponents Track Depression Symptom Severity.bioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Prefrontal Network Mechanisms of Psychiatric Deep Brain Stimulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Closing the loop in psychiatric deep brain stimulation: physiology, psychometrics, and plasticity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ashan VeerakumarDepartment of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia.
Vineet TiruvadiDepartment of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia.
Bryan HowellDepartment of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia.
Allison C WatersDepartment of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia.
Andrea L CrowellDepartment of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia.
Bradley VoytekDepartment of Cognitive Science, University of California San Diego, La Jolla, California.
Patricio Riva-PosseDepartment of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia.
Lydia DenisonDepartment of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia.
Justin K RajendraDepartment of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia.
Johnathan A EdwardsDepartment of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia.
Kelly R BijankiDepartment of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia.
Ki Sueng ChoiDepartment of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia.
Helen S MaybergDepartment of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008169 · NIGMS · EMORY UNIVERSITY · PI GROSS, ROBERT E · 1987 to 2021
$20.3M
Electrophysiological Biomarkers to Optimize DBS for DepressionUH3NS103550 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MAYBERG, HELEN S, RIVA-POSSE, PATRICIO · 2017 to 2023
$7.7M
Tractography-Activation Models for Neuropsychiatric Deep StimulationR01MH102238 · NIMH · DUKE UNIVERSITY · PI MCINTYRE, CAMERON · 2014 to 2025
$4.5M
CRCNS: Patient-Specfic Models of Local Field Potentials in Subcallosal CingulateR01MH106173 · NIMH · CASE WESTERN RESERVE UNIVERSITY · PI MCINTYRE, CAMERON · 2014 to 2019
$2.0M
Computational models of subcallosal cingulate deep brain stimulationF32NS096839 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI HOWELL, BRYAN · 2016 to 2018
$164k
Howard Hughes Medical InstituteNIGMS NIH HHS T32 GM008169NIMH NIH HHS R01 MH102238NIMH NIH HHS R01 MH106173NINDS NIH HHS F32 NS096839NINDS NIH HHS UH3 NS103550
6 · The paper itself

Abstract

Subcallosal cingulate cortex deep brain stimulation (SCC-DBS) is an experimental therapy for treatment-resistant depression (TRD). Refinement and optimization of SCC-DBS will benefit from increased study of SCC electrophysiology in context of ongoing high-frequency SCC-DBS therapy. The study objective was a 7-mo observation of frequency-domain 1/

Indexed as

Electrophysiological PhenomenaGyrus CinguliProcess Assessment, Health CareAgedDeep Brain StimulationDepressive Disorder, Treatment-ResistantFemaleHumansLongitudinal StudiesMaleMiddle Aged1/BA25deep brain stimulationdepressionLFPSCC

Identifiers

PMID31314668
PMCPMC6766743

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.