Evidence map›Paper›PMID 31314571›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2019

The developmentally regulated fetal enterocyte gene,

Frida Gorreja, Stephen Ta Rush, Dennis L Kasper, Di Meng, W Allan Walker

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Dynamics of the preterm gut microbiome in health and disease.American journal of physiology. Gastrointestinal and liver physiology · 2021
    Review
  8. Article
  9. EnterotoxigenicGut microbes · 2020
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Frida GorrejaSchool of Medical Sciences, Örebro University, Örebro, Sweden.
Stephen Ta RushSchool of Medical Sciences, Örebro University, Örebro, Sweden.
Dennis L KasperDepartment of Microbiology and Immunology, Boston, Massachusetts.
Di MengMucosal Immunology and Biology Research Center, Massachusetts General Hospital for Children, Boston, Massachusetts.
W Allan WalkerMucosal Immunology and Biology Research Center, Massachusetts General Hospital for Children, Boston, Massachusetts.
Harvard University · USMassachusetts General Hospital · USÖrebro University · SEUniversity of Gothenburg · SE

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6M
Xenograft and Isograft CoreP01DK033506 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI WALKER, W ALLAN · 1986 to 2015
$24.2M
MGHfC Digestive Disease Summer Research ProgramR25DK103579 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BRYAN P HURLEY · 2015 to 2026
$1.2M
NIDDK NIH HHS P01 DK033506NIDDK NIH HHS P30 DK040561NIDDK NIH HHS R25 DK103579
6 · The paper itself

Abstract

Initial colonizing bacteria play a critical role in completing the development of the immune system in the gastrointestinal tract of infants. Yet, the interaction of colonizing bacterial organisms with the developing human intestine favors inflammation over immune homeostasis. This characteristic of bacterial-intestinal interaction partially contributes to the pathogenesis of necrotizing enterocolitis (NEC), a devastating premature infant intestinal inflammatory disease. However, paradoxically some unique pioneer bacteria (initial colonizing species) have been shown to have a beneficial effect on the homeostasis of the immature intestine and the prevention of inflammation. We have reported that one such pioneer bacterium,

Indexed as

Anti-Inflammatory Agents, Non-SteroidalBacteroides fragilisCell LineChemokine CXCL5EnterocytesFetusGene Expression Regulation, DevelopmentalGene Knockdown TechniquesHumansInterleukin-1betaInterleukin-8PolysaccharidesToll-Like Receptor 2Toll-Like Receptor 4Zona Pellucida GlycoproteinsAnti-Inflammatory Agents, Non-SteroidalChemokine CXCL5CXCL5 protein, humanInterleukin-1betaInterleukin-8PolysaccharidesTLR2 protein, humanTLR4 protein, humanToll-Like Receptor 2Toll-Like Receptor 4Zona Pellucida GlycoproteinsZP4 protein, humanimmature enterocytesinitial intestinal colonizationnecrotizing enterocolitispolysaccharide Azona pellucida protein 4

Identifiers

PMID31314571
PMCPMC6842988
OpenAlexW2962471864

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.