ArticleEnvironmental health perspectives2019
Oral Systemic Bioavailability of Bisphenol A and Bisphenol S in Pigs.
Article in Environmental health perspectives, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Enteric Nervous System Damage by Food Contaminants: A Pathway to Neurodegeneration?Comprehensive reviews in food science and food safety · 2026Pooled it
- Bisphenol S fetal exposure in ewes exhibiting contrasted metabolic status impaired the ovarian follicular development of fetuses and lambs.Journal of ovarian research · 2026Article
- Bisphenols and follicle function in farm species.The Journal of reproduction and development · 2026Review
- Efficient magnetic sorbent for extracting bisphenol A from aqueous samples.RSC advances · 2025Article
- The Effect of Oral Administration of Bisphenol A and AF on Their Deposition in the Body Organs of Growing Pigs and the Relationship to Growth Rate.Animals : an open access journal from MDPI · 2025Article
- Oral exposure to bisphenol S is associated with alterations in the oviduct proteome of an ovine model, with aggravated effects in overfed females.BMC genomics · 2024Article
- Bisphenol A and its alternatives bisphenol S and F exposure with serum uric acid levels, hyperuricemia, and gout prevalence among US adults: a nationally representative cross-sectional study.BMC public health · 2024Article
- Article
- The intestinal microbiota as mediators between dietary contaminants and host health.Experimental biology and medicine (Maywood, N.J.) · 2023Review
- New environmental factors related to diabetes risk in humans: Emerging bisphenols used in synthesis of plastics.World journal of diabetes · 2023Article
- Endocrine disruptor chemicals as obesogen and diabetogen: Clinical and mechanistic evidence.World journal of clinical cases · 2022Review
- Glucuronidated Metabolites of Bisphenols A and S Alter the Properties of Normal Urothelial and Bladder Cancer Cells.International journal of molecular sciences · 2022Article
- Article
- Are BPA Substitutes as Obesogenic as BPA?International journal of molecular sciences · 2022Review
- Development and Validation of an Analytical Method for Quantitation of Bisphenol S in Rodent Plasma, Amniotic Fluid and Fetuses by UPLC-MS-MS.Journal of analytical toxicology · 2022Article
- Use of Mixture Dosing and Nonlinear Mixed Effect Modeling of Eight Environmental Contaminants in Rabbits to Improve Extrapolation Value of Toxicokinetic Data.Environmental health perspectives · 2021Article
- Pregnancy-specific physiologically-based toxicokinetic models for bisphenol A and bisphenol S.Environment international · 2021Article
- Bisphenol A, S or F mother's dermal impregnation impairs offspring immune responses in a dose and sex-specific manner in mice.Scientific reports · 2021Article
- Review: The Consumption of Ultra-Processed Foods and Non-communicable Diseases in Latin America.Frontiers in nutrition · 2021Review
- Comparative toxicokinetics of bisphenol S in rats and mice following gavage administration.Toxicology and applied pharmacology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGiven its hormonal activity, bisphenol S (BPS) as a substitute for bisphenol A (BPA) could actually increase the risk of endocrine disruption if its toxicokinetic (TK) properties, namely its oral availability and systemic persistency, were higher than those of BPA.
objectivesThe TK behavior of BPA and BPS was investigated by administering the two compounds by intravenous and oral routes in piglet, a known valid model for investigating oral TK.
methodsExperiments were conducted in piglets to evaluate the kinetics of BPA, BPS, and their glucuronoconjugated metabolites in plasma and urine after intravenous administration of BPA, BPS, and BPS glucuronide (BPSG) and gavage administration of BPA and BPS. A population semiphysiologically based TK model describing the disposition of BPA and BPS and their glucuronides was built from these data to estimate the key TK parameters that drive the internal exposure to active compounds.
resultsThe data indicated that almost all the BPS oral dose was absorbed and transported into the liver where only 41% of BPS was glucuronidated, leading to a systemic bioavailability of 57.4%. In contrast, only 77% of the oral dose of BPA was absorbed and underwent an extensive first-pass glucuronidation either in the gut (44%) or in the liver (53%), thus accounting for the low systemic bioavailability of BPA (0.50%). Due to the higher systemic availability of BPS, in comparison with BPA, and its lower plasma clearance (3.5 times lower), the oral BPS systemic exposure was on average about 250 times higher than for BPA for an equal oral molar dose of the two compounds.
conclusionGiven the similar digestive tracts of pigs and humans, our results suggest that replacing BPA with BPS will likely lead to increased internal exposure to an endocrine-active compound that would be of concern for human health. https://doi.org/10.1289/EHP4599.
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