Evidence map›Paper›PMID 31313880›Full record

ArticleGenesis (New York, N.Y. : 2000)2019

Generation and characterization of Lhx4

Xuhui Dong, Xiaoling Xie, Luming Guo, Jiadong Xu, Mei Xu, Guoqing Liang, Lin Gan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genesis (New York, N.Y. : 2000), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Inducible CreEReNeuro · 2026
    Article
  2. Inducible CreERbioRxiv : the preprint server for biology · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Xuhui DongCollege of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China.ORCID 0000-0002-2015-6868
Xiaoling XieDepartment of Ophthalmology and Flaum Eye Institute, University of Rochester, Rochester, New York.
Luming GuoCollege of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
Jiadong XuCollege of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
Mei XuDepartment of Ophthalmology and Flaum Eye Institute, University of Rochester, Rochester, New York.
Guoqing LiangInstitute of Life Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Lin GanDepartment of Ophthalmology and Flaum Eye Institute, University of Rochester, Rochester, New York.ORCID 0000-0001-5278-4554
Hangzhou Normal University · CNUniversity of Rochester · US

Funding

The Roles of LIM-Homeodomain Transcription Factors in Retinal DevelopmentR01EY026614 · NEI · UNIVERSITY OF ROCHESTER · PI GAN, LIN · 2016 to 2020
$1.9M
Department of Ophthalmology at the University of Rochester RO1EY026614NEI NIH HHS R01 EY026614
6 · The paper itself

Abstract

LHX4 is a LIM-homeodomain transcription factor essential for the development of spinal cord and pituitary gland. Mice with homozygous Lhx4-null mutation suffer early postnatal death from lung defect. In this study, to facilitate the research on Lhx4 function, we designed a targeting construct to generate two novel Lhx4 mouse lines: Lhx4

Indexed as

Genes, ReporterAnimalsGene Knock-In TechniquesIntegrasesLIM-Homeodomain ProteinsLuminescent ProteinsMiceMice, Inbred C57BLMice, KnockoutMutagenesis, InsertionalRed Fluorescent ProteinTranscription FactorsCre recombinaseIntegrasesLhx4 protein, mouseLIM-Homeodomain ProteinsLuminescent ProteinsRed Fluorescent ProteinTranscription FactorshomeoboxLIM-homeodomainpituitary glandretinaspinal cord

Identifiers

PMID31313880
PMCPMC6995401
OpenAlexW2958595101

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.