ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2020
Algorithm in the Diagnosis of Febrile Illness Using Pathogen-specific Rapid Diagnostic Tests.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05085158 (Pathogen Detection in HIV-infected Children and Adolescents With Non-malarial Febrile Illnesses Using Metagenomic Next-generation Sequencing Approach in Uganda), which is not on this map. Cited by 12 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pathogen Detection in HIV-infected Children and Adolescents With Non-malarial Febrile Illnesses Using Metagenomic Next-generation Sequencing Approach in Uganda
Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Article
- Comparative Analysis of Molecular Detection Algorithms for Enhanced Dengue Surveillance: A Field Case Evaluation.The American journal of tropical medicine and hygiene · 2026Article
- Adding Virome Capture Metagenomic Sequencing to Conventional Laboratory Testing Increases Unknown Fever Etiology Determination in Bamako, Mali.The American journal of tropical medicine and hygiene · 2025Article
- Leptospirosis Cases among Outpatients with Non-Malaria Fever Attending Primary Care Clinics during the Rainy Season in Bobo Dioulasso, Burkina Faso.The American journal of tropical medicine and hygiene · 2024Article
- Determinants of Aedes mosquito larval ecology in a heterogeneous urban environment- a longitudinal study in Bengaluru, India.PLoS neglected tropical diseases · 2023Article
- Better diagnostic tools needed to distinguish typhoid from other causes of acute febrile illness.Bulletin of the World Health Organization · 2023Article
- Two-test algorithms for infectious disease diagnosis: Implications for COVID-19.PLOS global public health · 2022Article
- Implementing radical cure diagnostics for malaria: user perspectives on G6PD testing in Bangladesh.Malaria journal · 2021Article
- Idiosyncratic Drug-Induced Liver Injury (DILI) and Herb-Induced Liver Injury (HILI): Diagnostic Algorithm Based on the Quantitative Roussel Uclaf Causality Assessment Method (RUCAM).Diagnostics (Basel, Switzerland) · 2021Review
- Diagnosing malaria and other febrile illnesses during the COVID-19 pandemic.The Lancet. Global health · 2020Article
- Spatial epidemiology of Japanese encephalitis virus and other infections of the central nervous system infections in Lao PDR (2003-2011): A retrospective analysis.PLoS neglected tropical diseases · 2020Article
- Outbreak of acute undifferentiated febrile illness in Kathmandu, Nepal: clinical and epidemiological investigation.BMC infectious diseases · 2020Article
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundIn the absence of proper guidelines and algorithms, available rapid diagnostic tests (RDTs) for common acute undifferentiated febrile illnesses are often used inappropriately.
methodsUsing prevalence data of 5 common febrile illnesses from India and Cambodia, and performance characteristics (sensitivity and specificity) of relevant pathogen-specific RDTs, we used a mathematical model to predict the probability of correct identification of each disease when diagnostic testing occurs either simultaneously or sequentially in various algorithms. We developed a web-based application of the model so as to visualize and compare output diagnostic algorithms when different disease prevalence and test performance characteristics are introduced.
resultsDiagnostic algorithms with appropriate sequential testing predicted correct identification of etiology in 74% and 89% of patients in India and Cambodia, respectively, compared with 46% and 49% with simultaneous testing. The optimally performing sequential diagnostic algorithms differed in India and Cambodia due to varying disease prevalence.
conclusionsSimultaneous testing is not appropriate for the diagnosis of acute undifferentiated febrile illnesses with presently available tests, which should deter the unsupervised use of multiplex diagnostic tests. The implementation of adaptive algorithms can predict better diagnosis and add value to the available RDTs. The web application of the model can serve as a tool to identify the optimal diagnostic algorithm in different epidemiological settings, while taking into account the local epidemiological variables and accuracy of available tests.
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