ArticleJournal of biomedical optics2019
Spatial frequency domain imaging: a quantitative, noninvasive tool for in vivo monitoring of burn wound and skin graft healing.
Article in Journal of biomedical optics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Quantitative optical property mapping of the periocular region using spatial frequency domain imaging.Journal of biomedical optics · 2026Article
- Optical and acoustic scattering in cutaneous neurofibromas: Implications for early detection.The Journal of investigative dermatology · 2026Article
- Two-step regression analysis approach to assess burn wound severity using spatial frequency domain imaging.Journal of biomedical optics · 2026Article
- Strategies for Optimizing Acute Burn Wound Therapy: A Comprehensive Review.Medicina (Kaunas, Lithuania) · 2025Review
- Evaluations of a Cutaneous Wound Healing Model Using Oxygen Enhanced - Dynamic Contrast Enhanced Photoacoustic Imaging (OE-DCE PAI).Molecular imaging and biology · 2024Article
- Using spatial frequency domain imaging to monitor a skin biopsy wound: a pilot study.Biomedical optics express · 2024Article
- Quantifying tissue properties and absolute hemodynamics using coherent spatial imaging.Journal of biomedical optics · 2023Article
- Current and Future Developments in Wound Healing.Facial plastic surgery : FPS · 2023Article
- Article
- Point-of-Care Ultrasound as a Tool to Assess Wound Size and Tissue Regeneration after Skin Grafting.Ultrasound in medicine & biology · 2021Article
- Quantitative diffuse optical spectroscopy for noninvasive measurements of the malaria pigment hemozoin.Biomedical optics express · 2020Article
- Article
- Special Section Guest Editorial: Special Section on Spatial Frequency Domain Imaging.Journal of biomedical optics · 2019Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
There is a need for noninvasive, quantitative methods to characterize wound healing in the context of longitudinal investigations related to regenerative medicine. Such tools have the potential to inform the assessment of wound status and healing progression and aid the development of new treatments. We employed spatial frequency domain imaging (SFDI) to characterize the changes in optical properties of tissue during wound healing progression in a porcine model of split-thickness skin grafts and also in a model of burn wound healing with no graft intervention. Changes in the reduced scattering coefficient measured using SFDI correlated with structural changes reported by histology of biopsies taken concurrently. SFDI was able to measure spatial inhomogeneity in the wounds and predicted heterogeneous healing. In addition, we were able to visualize differences in healing rate, depending on whether a wound was debrided and grafted, versus not debrided and left to heal without intervention apart from topical burn wound care. Changes in the concentration of oxy- and deoxyhemoglobin were also quantified, giving insight into hemodynamic changes during healing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.