ArticleBirth defects research2019
Nuclear radiation and prevalence of structural birth defects among infants born to women from the Marshall Islands.
Article in Birth defects research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Article
- Multicomponent Informed Consent with Marshallese Participants.Journal of empirical research on human research ethics : JERHRE · 2021Article
- Relative Biological Effectiveness of High LET Particles on the Reproductive System and Fetal Development.Life (Basel, Switzerland) · 2020Review
- Article
- Radiation-Induced Cerebro-Ophthalmic Effects in Humans.Life (Basel, Switzerland) · 2020Review
- Review of evidence for environmental causes of uveal coloboma.Survey of ophthalmologyReview
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Authors and funding
10 authors.
Funding
Abstract
backgroundWith their unique history of exposure to extensive nuclear testing between 1946 and 1958, descendants of Marshall Island residents may have underappreciated genetic abnormalities, increasing their risk of birth defects.
methodsWe conducted a retrospective cohort study of resident women with at least one singleton live birth between 1997 and 2013 in northwest Arkansas using state birth certificate data linked to data from the Arkansas Reproductive Health Monitoring System, a statewide birth defects registry. We calculated unadjusted and adjusted prevalence ratios (PR) and 95% confidence intervals (CI) from modified Poisson regression analyses for non-Hispanic (NH) whites, NH-blacks, Hispanics and Marshallese, using NH-whites as the reference group.
resultsOf the 91,662 singleton births during the study period, 2,488 were to Marshallese women. Due to the relatively small number of Marshallese births, we could not calculate prevalence estimates for some defects. Marshallese infants had higher rates of congenital cataracts (PR = 9.3; 95% CI: 3.1, 27.9). Although the number of defects was low, Marshallese infants also had higher rates of truncus arteriosus (PR = 44.0; 95% CI: 2.2, 896.1).
conclusionsMarshallese infants may have increased risk of specific birth defects, but estimates are unstable because of small sample size so results are inconclusive. Larger population-based studies would allow for further investigation of this potential risk among Marshallese infants.
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