Evidence map›Paper›PMID 31313401›Full record

ArticleMolecular carcinogenesis2019

Targeting cholecystokinin-2 receptor for pancreatic cancer chemoprevention.

Altaf Mohammed, Naveena B Janakiram, Chen Suen, Nicole Stratton, Stanley Lightfoot, Anil Singh, Gopal Pathuri, Rebekah Ritchie, Venkateshwar Madka, Chinthalapally V Rao

Open access · greenAbstract read
In one paragraph

Article in Molecular carcinogenesis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. A Novel CCK Receptor GPR173 Mediates Potentiation of GABAergic Inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Altaf MohammedDivision of Cancer Prevention, Chemoprevention Agent Development Research Group, National Cancer Institute, Bethesda, Maryland.ORCID 0000-0003-1058-6909
Naveena B JanakiramCenter for Cancer Prevention and Drug Development, Hem-Onc Section, Department of Medicine, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, VA Medical Center, Oklahoma City, Oklahoma.
Chen SuenDivision of Cancer Prevention, Chemoprevention Agent Development Research Group, National Cancer Institute, Bethesda, Maryland.
Nicole StrattonCenter for Cancer Prevention and Drug Development, Hem-Onc Section, Department of Medicine, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, VA Medical Center, Oklahoma City, Oklahoma.
Stanley LightfootCenter for Cancer Prevention and Drug Development, Hem-Onc Section, Department of Medicine, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, VA Medical Center, Oklahoma City, Oklahoma.
Anil SinghCenter for Cancer Prevention and Drug Development, Hem-Onc Section, Department of Medicine, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, VA Medical Center, Oklahoma City, Oklahoma.
Gopal PathuriCenter for Cancer Prevention and Drug Development, Hem-Onc Section, Department of Medicine, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, VA Medical Center, Oklahoma City, Oklahoma.
Rebekah RitchieCenter for Cancer Prevention and Drug Development, Hem-Onc Section, Department of Medicine, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, VA Medical Center, Oklahoma City, Oklahoma.
Venkateshwar MadkaCenter for Cancer Prevention and Drug Development, Hem-Onc Section, Department of Medicine, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, VA Medical Center, Oklahoma City, Oklahoma.
Chinthalapally V RaoCenter for Cancer Prevention and Drug Development, Hem-Onc Section, Department of Medicine, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, VA Medical Center, Oklahoma City, Oklahoma.ORCID 0000-0002-5715-7979
University of Oklahoma Health Sciences Center · USPrevention Group · US

Funding

Proteomics CoreP20GM103447 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI David W Dyer · 2012 to 2026
$60.2M
Tissue Pathology Shared ResourceP30CA225520 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Wade Williams · 2018 to 2026
$27.1M
Safer Approaches to CRC ChemopreventionR01CA213987 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI RAO, CHINTHALAPALLY V. · 2017 to 2021
$2.4M
Targeting mPGES-1/5-LOX for Prevention of CRC in High-Risk VeteransI01BX003198 · VA · OKLAHOMA CITY VA MEDICAL CENTER · PI RAO, CHINTHALAPALLY V. · 2016 to 2020
–
BLRD VA I01 BX003198NCI NIH HHS HHSN261201200013INCI NIH HHS P30 CA225520NCI NIH HHS R01 CA213987NIGMS NIH HHS P20 GM103447
6 · The paper itself

Abstract

Gastrin signaling mediated through cholecystokinin-2 receptor (CCK2R) and its downstream molecules is altered in pancreatic cancer. CCK2R antagonists, YF476 (netazepide) and JNJ-26070109, were tested systematically for their effect on pancreatic intraepithelial neoplasia (PanIN) progression to pancreatic ductal adenocarcinoma (PDAC) in Kras

Indexed as

AdenocarcinomaAnimalsBenzodiazepinonesCarcinoma in SituCarcinoma, Pancreatic DuctalChemopreventionDisease Models, AnimalFemaleGene Expression Regulation, NeoplasticHumansMiceNeoplasm ProteinsPancreatic NeoplasmsPhenylurea CompoundsProto-Oncogene Proteins p21(ras)Quinoxalines4-bromo-N-(1-(2,4-difluoro-phenyl)ethyl)-2-(quinoxaline-5-sulfonylamino)benzamideBenzodiazepinonesHras protein, mouseNeoplasm ProteinsPhenylurea CompoundsProto-Oncogene Proteins p21(ras)QuinoxalinesReceptor, Cholecystokinin BSulfonamidesYF 476CCK2Rchemopreventionkraspancreatic cancer

Identifiers

PMID31313401
PMCPMC6721979
OpenAlexW2958981879

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.