Evidence map›Paper›PMID 31313397›Full record

ArticleJournal of magnetic resonance imaging : JMRI2020

Utility of deep learning super-resolution in the context of osteoarthritis MRI biomarkers.

Akshay S Chaudhari, Kathryn J Stevens, Jeff P Wood, Amit K Chakraborty, Eric K Gibbons, Zhongnan Fang, Arjun D Desai, Jin Hyung Lee, Garry E Gold, Brian A Hargreaves

Open access · greenAbstract read
In one paragraph

Article in Journal of magnetic resonance imaging : JMRI, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
6.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 70 citations in OpenAlex.

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  7. Deep Learning-Based Image Reconstruction in Musculoskeletal MRI.Journal of the Korean Society of Radiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Akshay S ChaudhariDepartment of Radiology, Stanford University, Stanford, California, USA.ORCID 0000-0002-3667-6796
Kathryn J StevensDepartment of Radiology, Stanford University, Stanford, California, USA.
Jeff P WoodAustin Radiological Association, Austin, Texas, USA.
Amit K ChakrabortyDepartment of Radiology, Stanford University, Stanford, California, USA.
Eric K GibbonsDepartment of Radiology and Imaging Sciences, University of Utah, Salt Lake City, Utah, USA.
Zhongnan FangLVIS Corp., Palo Alto, California, USA.
Arjun D DesaiDepartment of Radiology, Stanford University, Stanford, California, USA.
Jin Hyung LeeDepartment of Neurology & Neurological Sciences, Stanford University, Stanford, California, USA.
Garry E GoldDepartment of Radiology, Stanford University, Stanford, California, USA.
Brian A HargreavesDepartment of Radiology, Stanford University, Stanford, California, USA.
Stanford Medicine · USPalo Alto Veterans Institute for Research · USTexas Medical Association · USUniversity of Utah · US

Funding

Training and DisseminationP41EB015891 · NIBIB · STANFORD UNIVERSITY · PI GLOVER, GARY H · 2012 to 2019
$10.7M
TRAINING IN CARDIOVASCULAR RESEARCHT32HL007576 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Stavros George Drakos, Robin M Shaw · 1985 to 2026
$10.6M
Rapid MRI for Evaluation of OsteoarthritisR01EB002524 · NIBIB · STANFORD UNIVERSITY · PI Akshay Chaudhari, Garry E Gold · 2003 to 2026
$10.1M
Rapid Low-Cost Quantitative 3D MRI and Gait Assessment of the KneeR01AR077604 · NIAMS · STANFORD UNIVERSITY · PI HARGREAVES, BRIAN ANDREW · 2020 to 2024
$3.2M
Quantitative 3D Diffusion and Relaxometry MRI of the KneeR01AR063643 · NIAMS · STANFORD UNIVERSITY · PI HARGREAVES, BRIAN ANDREW · 2013 to 2017
$2.5M
Advanced MR Imaging of Early OsteoarthritisK24AR062068 · NIAMS · STANFORD UNIVERSITY · PI GOLD, GARRY E · 2012 to 2022
$1.7M
CLINICAL CENTER FOR THE OSTEOARTHRITIS-264022262-264022262N01AR022262 · NIAMS · THE MEMORIAL HOSPITAL · PI ASSAF, ANNLOUISE R. · 2002 to 2006
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CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVE-N01AR22261N01AR022261 · NIAMS · OHIO STATE UNIVERSITY RESEARCH · PI JACKSON, REBECCA · 2002 to 2006
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CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVE-N01AR22260N01AR022260 · NIAMS · UNIVERSITY OF PITTSBURGH · PI KWOH, KENT · 2002 to 2006
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CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVE-264022259-264022259N01AR022259 · NIAMS · UNIVERSITY OF MARYLAND AT BALT · PI HOCHBERG, MARC C. · 2002 to 2006
–
DATA COORDINATING CENTER FOR THE OSTEOARTHRITIS INITIATIVE-264022258N01AR022258 · NIAMS · UNIVERSITY OF CALIFORNIA SYS OFFICE/PRES · 2003 to 2003
–
NHLBI NIH HHS T32 HL007576NIAMS NIH HHS K24 AR062068NIAMS NIH HHS N01 AR022258NIAMS NIH HHS N01 AR022259NIAMS NIH HHS N01 AR022260NIAMS NIH HHS N01 AR022261NIAMS NIH HHS N01 AR022262NIAMS NIH HHS R01 AR063643NIAMS NIH HHS R01 AR077604NIBIB NIH HHS P41 EB015891NIBIB NIH HHS R01 EB002524NIH HHS K24 AR062068NIH HHS N01 AR-2-2258NIH HHS N01 AR-2-2260NIH HHS N01 AR-2-2261NIH HHS N01 AR-2-2262NIH HHS P41 EB015891NIH HHS R01 AR063643NIH HHS R01 EB002524
6 · The paper itself

Abstract

backgroundSuper-resolution is an emerging method for enhancing MRI resolution; however, its impact on image quality is still unknown. PURPOSE: To evaluate MRI super-resolution using quantitative and qualitative metrics of cartilage morphometry, osteophyte detection, and global image blurring. STUDY TYPE: Retrospective. POPULATION: In all, 176 MRI studies of subjects at varying stages of osteoarthritis. FIELD STRENGTH/SEQUENCE: Original-resolution 3D double-echo steady-state (DESS) and DESS with 3× thicker slices retrospectively enhanced using super-resolution and tricubic interpolation (TCI) at 3T. ASSESSMENT: A quantitative comparison of femoral cartilage morphometry was performed for the original-resolution DESS, the super-resolution, and the TCI scans in 17 subjects. A reader study by three musculoskeletal radiologists assessed cartilage image quality, overall image sharpness, and osteophytes incidence in all three sets of scans. A referenceless blurring metric evaluated blurring in all three image dimensions for the three sets of scans. STATISTICAL TESTS: Mann-Whitney U-tests compared Dice coefficients (DC) of segmentation accuracy for the DESS, super-resolution, and TCI images, along with the image quality readings and blurring metrics. Sensitivity, specificity, and diagnostic odds ratio (DOR) with 95% confidence intervals compared osteophyte detection for the super-resolution and TCI images, with the original-resolution as a reference.

resultsDC for the original-resolution (90.2 ± 1.7%) and super-resolution (89.6 ± 2.0%) were significantly higher (P < 0.001) than TCI (86.3 ± 5.6%). Segmentation overlap of super-resolution with the original-resolution (DC = 97.6 ± 0.7%) was significantly higher (P < 0.0001) than TCI overlap (DC = 95.0 ± 1.1%). Cartilage image quality for sharpness and contrast levels, and the through-plane quantitative blur factor for super-resolution images, was significantly (P < 0.001) better than TCI. Super-resolution osteophyte detection sensitivity of 80% (76-82%), specificity of 93% (92-94%), and DOR of 32 (22-46) was significantly higher (P < 0.001) than TCI sensitivity of 73% (69-76%), specificity of 90% (89-91%), and DOR of 17 (13-22). DATA

conclusionSuper-resolution appears to consistently outperform naïve interpolation and may improve image quality without biasing quantitative biomarkers. LEVEL OF EVIDENCE: 2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2020;51:768-779.

Indexed as

Deep LearningOsteoarthritisBiomarkersHumansMagnetic Resonance ImagingReproducibility of ResultsRetrospective StudiesBiomarkersartificial intelligencecartilage segmentationimage accelerationmachine learning interpretabilityosteoarthritis biomarkerssuper-resolution

Identifiers

PMID31313397
PMCPMC6962563
OpenAlexW2959938807

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.