SynthesisJournal of veterinary internal medicine2019
Clinical effect of probiotics in prevention or treatment of gastrointestinal disease in dogs: A systematic review.
Synthesis in Journal of veterinary internal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Efficacy of probiotic, prebiotic, synbiotic and postbiotic supplementation on gastrointestinal health in cats: systematic review and meta-analysis.The Journal of small animal practice · 2025Pooled it
- Clinical effect of probiotics in prevention or treatment of gastrointestinal disease in dogs: A systematic review.Journal of veterinary internal medicine · 2019Pooled it
- A new highly digestible prescription diet containingFrontiers in veterinary science · 2025Trial
- Fecal Microbiota Transplantation in Dogs and Cats: Evidence for Gastrointestinal and Emerging Extra-Intestinal Applications.Animals : an open access journal from MDPI · 2026Review
- Impact of Combined Botanical Functional Ingredients on the Canine Gut Microbiome.Veterinary sciences · 2026Article
- Randomised controlled trial finds no evidence that a synbiotic improves health in assistance dog puppies.The Veterinary record · 2026Article
- Supplement use is common in Dog Aging Project participants, especially among dogs with orthopedic conditions, and varies by life stage.American journal of veterinary research · 2026Article
- Effects ofMicroorganisms · 2025Article
- The Impact of a Multi-Strain Probiotic Supplementation on Puppies Manifesting Diarrhoeic Symptoms During the Initial Seven Days of Life.Animals : an open access journal from MDPI · 2025Article
- Evaluating the safety and functionality of a novel compound containing prebiotics, probiotics, and postbiotics in healthy cats and dogs.Open veterinary journal · 2025Article
- Use of biotics in animals: impact on nutrition, health, and food production.Journal of animal science · 2025Review
- The alleviating effects and mechanisms ofFrontiers in veterinary science · 2025Article
- The Function of Probiotics and Prebiotics on Canine Intestinal Health and Their Evaluation Criteria.Microorganisms · 2024Review
- Assessing the effects of probiotic supplementation, single strain versus mixed strains, on femoral mineral density and osteoblastic gene mRNA expression in rats.Journal of bone and mineral metabolism · 2024Article
- Updating the Classification of Chronic Inflammatory Enteropathies in Dogs.Animals : an open access journal from MDPI · 2024Review
- Effects of dietary fiber and biotic supplementation on apparent total tract macronutrient digestibility and the fecal characteristics, metabolites, and microbiota of healthy adult dogs.Journal of animal science · 2024Article
- Species-level characterization of the core microbiome in healthy dogs using full-length 16S rRNA gene sequencing.Frontiers in veterinary science · 2024Article
- Antimicrobial Effects of Plant-Based Supplements on Gut Microbial Diversity in Small Ruminants.Pathogens (Basel, Switzerland) · 2023Review
- A multi-strain probiotic promoted recovery of puppies from gastroenteritis in a randomized, double-blind, placebo-controlled study.The Canadian veterinary journal = La revue veterinaire canadienne · 2023Article
- A retrospective evaluation of mushroom ingestions in 421 dogs in Norway (2011-2022).Veterinary record open · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGastrointestinal diseases are prevalent in dogs, and probiotics could provide safe alternatives to conventional treatments.
objectiveTo evaluate the clinical effects of probiotics when used in the prevention or treatment of gastrointestinal disease in dogs compared with no treatment, only symptomatic treatment, or conventional treatment.
methodsA systematic review was preformed searching AGRICOLA, AGRIS, CAB Abstracts, Embase, Ovid MEDLINE, and Web of Science to identify articles published before April 1, 2017. Selection criteria were original research report, those published in peer reviewed journal, and study investigating in vivo use of probiotic for prevention or treatment of gastrointestinal disease in dogs. Studies were rated based on the level of evidence, and methodological quality was evaluated by the following variables: similarities between groups at baseline, risk of bias, and study group size.
resultsOne hundred sixty-five studies were identified, of which 17 met the inclusion criteria-12 concerned acute gastrointestinal disease and 5 concerned chronic gastrointestinal disease. The level of evidence ranged between randomized controlled studies and crossover uncontrolled trials; estimated risk of bias was generally moderate to high; and sample sizes were small. Feces consistency was the most frequently evaluated clinical variable. CONCLUSIONS AND CLINICAL IMPORTANCE: The current data point toward a very limited and possibly clinically unimportant effect for prevention or treatment of acute gastrointestinal disease. For chronic gastrointestinal disease, dietary intervention remains the major key in treatment, whereas probiotic supplement seems not to add significant improvement. However, studies were often underpowered, underscoring the need for future larger, preferably multicenter studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.