Evidence map›Paper›PMID 31313217›Full record

ArticleJournal of muscle research and cell motility2020

Mitochondria and autophagy in adult stem cells: proliferate or differentiate.

Mark A Lampert, Åsa B Gustafsson

Open access · greenAbstract read
In one paragraph

Article in Journal of muscle research and cell motility, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Unravelling the Interplay between Cardiac Metabolism and Heart Regeneration.International journal of molecular sciences · 2023
    Review
  5. Article
  6. Review
  7. Article
  8. Dissecting molecular mechanisms underlying HStem cell research & therapy · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Mark A LampertSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive #0751, La Jolla, CA, 92093-0751, USA.
Åsa B GustafssonSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive #0751, La Jolla, CA, 92093-0751, USA. asag@ucsd.edu.
University of California, San Diego · US

Funding

Surgery, Physiology and ImmunohistopathologyP01HL085577 · NHLBI · SAN DIEGO STATE UNIVERSITY · PI BROWN, JOAN HELLER · 2006 to 2017
$18.4M
GRADUATE TRAINING IN CELLULAR &MOLECULAR PHARMACOLOGYT32GM007752 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BROWN, JOAN HELLER, HANDEL, TRACY M · 1985 to 2023
$13.5M
Role of Bnip3 in Myocardial Ischemia/ReperfusionR01HL087023 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GUSTAFSSON, ASA B. · 2007 to 2016
$3.8M
MCL-1 is a critical regulator of mitochondrial dynamics and function in myocytesR01HL132300 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GUSTAFSSON, ASA B. · 2017 to 2020
$1.7M
Role of the Endosomal-Lysosomal Pathway in Mitochondrial Quality ControlR01HL138560 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GUSTAFSSON, ASA B. · 2017 to 2020
$1.6M
Mitochondrial Quality Control in the Aging MyocardiumR21AG052280 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GUSTAFSSON, ASA B. · 2016 to 2017
$426k
Beclin1 and UVRAG Regulate Rab5 and the Endosomal Degradation PathwayF31HL145973 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LAMPERT, MARK ANDREW · 2019 to 2020
$46k
NHLBI NIH HHS F31 HL145973NHLBI NIH HHS P01 HL085577NHLBI NIH HHS R01 HL087023NHLBI NIH HHS R01 HL132300NHLBI NIH HHS R01 HL138560NIA NIH HHS R21 AG052280NIGMS NIH HHS T32 GM007752NIH HHS P01HL085577
6 · The paper itself

Abstract

Adult stem cells are undifferentiated cells that are found in many different tissues after development. They are responsible for regenerating and repairing tissues after injury, as well as replacing cells when needed. Adult stem cells maintain a delicate balance between self-renewal to prevent depletion of the stem cell pool and differentiation to continually replenish downstream lineages. The important role of mitochondria in generating energy, calcium storage and regulating cell death is well established. However, new research has linked mitochondria to stem cell maintenance and fate. In addition, efficient mitochondrial quality control is critical for stem cell homeostasis to ensure their long-term survival in tissues. In this review, we discuss the latest evidence linking mitochondrial function, remodeling and turnover via autophagy to regulation of adult stem cell self-renewal and differentiation.

Indexed as

AnimalsAutophagyCell DifferentiationCell ProliferationDNA Mutational AnalysisHumansMiceMitochondriaAdult stem cellsAutophagyGlycolysisMitochondriaMitophagyOxidative phosphorylation

Identifiers

PMID31313217
PMCPMC6962576
OpenAlexW2959210034

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.