ArticleDigestive diseases and sciences2020
Predictive Factors of Mild and Severe Fibrosis in Colorectal Endoscopic Submucosal Dissection.
Article in Digestive diseases and sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Review on colorectal endoscopic submucosal dissection focusing on the technical aspect.Surgical endoscopy · 2020Pooled it
- Development and validation of a predictive scoring model for post-ESD coagulation syndrome in elderly with colorectal LSTs.International journal of colorectal disease · 2026Article
- Time Prediction Accuracy and Influencing Factors in Colorectal ESD by Trainees: A Mixed-Model Analysis.Digestive diseases and sciences · 2026Article
- A nomogram to predict submucosal fibrosis in early gastric cancer undergoing endoscopic submucosal dissection.Scientific reports · 2025Article
- Optimizing Endoscopic Submucosal Dissection Outcomes: Focus on Iatrogenic Fibrosis and Intervention Timing.Digestive diseases and sciences · 2025Article
- Article
- Submucosal fibrosis in large colorectal serrated lesions in cases receiving endoscopic submucosal dissection.Therapeutic advances in gastroenterology · 2025Article
- Development and validation of a predictive model for submucosal fibrosis in patients with early gastric cancer undergoing endoscopic submucosal dissection: experience from a large tertiary center.Annals of medicine · 2024Article
- Outcome and predictive factors for perforation in orthodontic rubber band-assisted endoscopic submucosal dissection of fibrotic colorectal lesions.Scientific reports · 2024Article
- The Derivation and External Validation of a Fibrosis Risk Model for Colorectal Tumours Undergoing Endoscopic Submucosal Dissection.Journal of clinical medicine · 2024Article
- Effectiveness of Strategy-Focused Training in Colorectal Endoscopic Submucosal Dissection: A Retrospective Observational Study.Digestive diseases and sciences · 2024Observational
- Outcomes in colorectal endoscopic submucosal dissection for large protruded lesions: A retrospective multicenter study.Endoscopy international open · 2024Article
- Feasibility and Safety of Endoscopic Control for Patients with Serrated Polyposis Syndrome.Digestive diseases (Basel, Switzerland) · 2024Article
- Novel beagle model of gastric local fibrotic target lesions for the evaluation and training of endoscopic techniques.BMC gastroenterology · 2023Article
- Predicting procedure duration of colorectal endoscopic submucosal dissection at Western endoscopy centers.Endoscopy international open · 2023Article
- Outcomes and Learning Curve in Endoscopic Submucosal Dissection of Rectal Neoplasms with Severe Fibrosis: Experience of a Western Center.GE Portuguese journal of gastroenterology · 2023Article
- Left colonic localization, non-granular morphology, and pit pattern independently predict submucosal fibrosis of naïve colorectal neoplasms before endoscopic submucosal dissection.Surgical endoscopy · 2023Article
- Factors for conversion risk of colorectal endoscopic submucosal dissection: a multicenter study.Surgical endoscopy · 2022Article
- The feasibility of endoscopic submucosal dissection for colorectal lesions larger than 10 cm.Surgical endoscopy · 2022Article
- Hybrid endoscopic submucosal dissection: An alternative resection modality for large laterally spreading tumors in the cecum?BMC gastroenterology · 2021Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND STUDY
aimsVarying degrees of fibrosis in colorectal endoscopic submucosal dissection (ESD) make the procedure difficult. Consensus on the predictive factors of fibrosis degree (mild or severe) has not been established. We conducted a study to identify the predictive factors and to examine the feasibility of ESD for fibrotic lesions. PATIENTS AND
methodsWe included 518 patients who had undergone ESD for 558 lesions from April 2012-September 2018. Patients were classified into fibrosis or no-fibrosis groups, and logistic regression analysis was performed to identify predictive factors of fibrosis. Subgroup analyses were performed for fibrosis degree.
resultsThe total incidence of fibrosis was 21.1% (mild: 14.1%; severe: 7.1%). Although the curative resection rate (free margin: invasion depth less than 1000 μm: no lymphatic invasion, vascular involvement) was lower in the fibrosis group compared with the control (80.7% vs. 97.6%), neither the en bloc resection rate (99.1% vs. 100%) nor incidence of perforation (0.9% vs. 0.2%) differed between the two groups. Multivariate analysis revealed that a cecal location, preoperative biopsy, straddling fold, laterally spreading tumor-non-granular-pseudo-depressed (LST-NG-PD) type were predictive of mild fibrosis. The presence of a straddling fold and a protruded lesion were independent predictive factors of severe fibrosis.
conclusionsWe identified the predictive factors of mild and severe fibrosis. It is preferable that a more experienced physician performs ESD for the lesions with F2 fibrosis.
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