Evidence map›Paper›PMID 31312984›Full record

ArticleJournal of molecular modeling2019

Theoretical study on the mechanism of N- and α-carbon oxidation of lapatinib catalyzed by cytochrome P450 monooxygenase.

Hong Huang, Xue Bai, Lijun Yang

Abstract read
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In one paragraph

Article in Journal of molecular modeling, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Hong HuangChemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, China West Normal University, Nanchong, 637009, Sichuan, People's Republic of China.
Xue BaiChemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, China West Normal University, Nanchong, 637009, Sichuan, People's Republic of China.
Lijun YangChemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, China West Normal University, Nanchong, 637009, Sichuan, People's Republic of China. ljyang@cwnu.edu.cn.ORCID http://orcid.org/0000-0001-5162-8242
China West Normal University · CN

Funding

Meritocracy Research Funds of China West Normal University 17YC037
6 · The paper itself

Abstract

Lapatinib, an orally active dual tyrosine kinase inhibitor, is efficacious in combination therapy with capecitabine for advanced metastatic breast cancer. Despite its importance, it has been associated with hepatotoxicity observed in clinical trials and postmarketing surveillance. The mechanisms of hepatotoxicity at the chemical and cellular levels may link to drug metabolism. In this study, the N- and α-carbon oxidation processes of lapatinib catalyzed by CYP3A4 were explored by density functional theory method. The calculation results show that oxidation of C

Indexed as

BiocatalysisModels, TheoreticalCarbonCytochrome P-450 Enzyme SystemFuraldehydeHydrogenHydroxylationLapatinibMetabolic Networks and PathwaysMolecular ConformationNitrogen OxidesOxidation-ReductionThermodynamicsCarbonCytochrome P-450 Enzyme SystemFuraldehydeHydrogenLapatinibNitrogen OxidesnitronesActive metaboliteDensity functional theoryLapatinibN- and α-carbon oxidation

Identifiers

PMID31312984
OpenAlexW2961850731

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.