Evidence map›Paper›PMID 31312969›Full record

SynthesisClinical oral investigations2020

Second primary molar hypomineralisation and drugs used during pregnancy and infancy. A systematic review.

Clara Serna Muñoz, Antonio J Ortiz Ruiz, Amparo Pérez Silva, Luis Alberto Bravo-González, Ascensión Vicente

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Clinical oral investigations, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Clara Serna MuñozDepartment of Integral Paediatric Dentistry, University Dental Clinic, University of Murcia, Hospital Morales Meseguer, 2a planta, C/ Marqués de los Vélez, s/n., 30007, Murcia, Spain.
Antonio J Ortiz RuizDepartment of Integral Paediatric Dentistry, University Dental Clinic, University of Murcia, Hospital Morales Meseguer, 2a planta, C/ Marqués de los Vélez, s/n., 30007, Murcia, Spain. ajortiz@um.es.
Amparo Pérez SilvaDepartment of Integral Paediatric Dentistry, University Dental Clinic, University of Murcia, Hospital Morales Meseguer, 2a planta, C/ Marqués de los Vélez, s/n., 30007, Murcia, Spain.
Luis Alberto Bravo-GonzálezDepartment of Orthodontics, Faculty of Medicine, University of Murcia, Murcia, Spain.
Ascensión VicenteDepartment of Orthodontics, Faculty of Medicine, University of Murcia, Murcia, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesHypomineralised second primary molars (HSPM) are due to idiopathic hypomineralisation that affects from 1- to 4-s primary molars, and its aetiology remains unclear. Our objective was to systematically review studies in which the investigators had studied the association between HSPM and drug use during pregnancy and the first year of life. MATERIALS AND

methodsA systematic search for publications until July 2018 was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. No restrictions were placed on year of publication. The PECO Question was as follows: P, children exposed to drugs during pregnancy and the first year of life; E, drugs to which mothers, during pregnancy and their offspring were exposed; C, control groups from studies with the same characteristics not exposed to drugs during pregnancy and the first year of life; and O, relationship between drug exposure during pregnancy and the first year of life and HSPM. Two reviewers extracted the data and assessed the risk of bias using the Newcastle-Ottawa Scale criteria.

resultsWe initially identified 986 articles, or which seven were selected for review: two case-control studies, one cross-sectional studies and four cohort studies. Four studies reported data on drug consumption during pregnancy and four investigated drug use during the first year of life and the occurrence of enamel defects in primary dentition.

conclusionsThere is no clear evidence that the use of drugs during pregnancy and during the first year of life is associated with HSPM. Further well-designed prospective studies are needed. CLINICAL RELEVANCE: Determining the etiological factors related to the development of HSPM would help to establish preventive protocols in patients at potential risk. As HSPM is predictive of molar incisor hypomineralisation (MIH), the application of preventive protocols would avoid complications in both the primary and permanent dentition.

Indexed as

Pharmaceutical PreparationsChildCross-Sectional StudiesDental Enamel HypoplasiaFemaleHumansMaternal ExposureMolarPregnancyPrevalenceProspective StudiesTooth, DeciduousPharmaceutical PreparationsDeciduous molar hypomineralisationDrugsHypomineralised second primary molars

Identifiers

PMID31312969

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.