ReviewInflammation research : official journal of the European Histamine Research Society ... [et al.]2019
Regulation of C-reactive protein conformation in inflammation.
Review in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
75 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- The role of inflammatory biomarkers in the development and progression of pre-eclampsia: a systematic review and meta-analysis.Frontiers in immunology · 2023Pooled it
- CRP (C-Reactive Protein) Revisited: An Old Yet New Biomarker of Acute and Chronic Inflammation.Cells · 2026Review
- Elevated admission C-reactive protein identifies complicated or high-risk acute Stanford type B aortic dissection.Frontiers in immunology · 2026Observational
- Porcine genetic markers of immunocompetence shape the immune response to a classical swine fever virus subunit vaccine.Frontiers in cellular and infection microbiology · 2026Article
- The mechanism of electrical remodeling in atrial fibrillation and current research status of natural drugs and active ingredients inhibiting atrial electrical remodeling.Frontiers in cardiovascular medicine · 2026Review
- PLR/SII/D-dimer iron triangle: a novel precision prediction strategy forFrontiers in medicine · 2026Article
- Elevated C-Reactive Protein-Albumin-Lymphocyte Index Is Associated With Reduced Mortality in Chronic Inflammatory Airway Diseases: A Population-Based Observational Study.Mediators of inflammation · 2026Observational
- C-reactive protein to albumin ratio as a predictor of early postoperative wound complications in patients undergoing posterior lumbar spine surgery.Frontiers in surgery · 2026Article
- Disease-specific biomarker value of C-reactive protein and its composite indices in autoinflammatory diseases: an integrated study of multi-modal omics and population cohorts.Frontiers in immunology · 2026Article
- Monomeric C-reactive Protein Exacerbates Neuronal Injury and Enhances Microglial Activation after Global Cerebral Ischemia in Mice.Molecular neurobiology · 2025Article
- Manganese Exposure Is Associated with Reduced Grip Strength: Evidence from Humans and Mice.Toxics · 2025Article
- Influence of Acute Phase Proteins on Neutrophil Function In Vitro.FASEB bioAdvances · 2025Article
- C-reactive protein-to-lymphocyte ratio and hemoglobin-to-red cell distribution width ratio as effective prognostic predictors in pediatric patients with neuroblastoma.European journal of pediatrics · 2025Article
- Longitudinal and concurrent C-reactive protein and diet associations with cognitive function in the population-based Tromsø study.Journal of Alzheimer's disease : JAD · 2025Article
- Association of inflammatory risk based on the Glasgow Prognostic Score with long-term mortality in patients with cardiovascular disease.Scientific reports · 2025Article
- Optical Bionanosensors for Sepsis Diagnostics.Small (Weinheim an der Bergstrasse, Germany) · 2025Review
- Integrated transcriptomic analysis of COVID-19 stages and recovery: insights into key gene signatures, immune features, and diagnostic biomarkers through machine learning.Frontiers in genetics · 2025Article
- Inflammatory storm and metabolic disorders: unraveling heterogeneity in mortality risk for comorbid diabetes mellitus and heart failure via the C-reactive protein-triglyceride-glucose index.Frontiers in endocrinology · 2025Article
- Serum biomarkers and postherpetic neuralgia in herpes zoster patients with immunocompetent.Frontiers in neurology · 2025Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
C-reactive protein (CRP) is a non-specific diagnostic marker of inflammation and an evolutionarily conserved protein with roles in innate immune signaling. Natural CRP is composed of five identical globular subunits that form a pentamer, but the role of pentameric CRP (pCRP) during inflammatory pathogenesis remains controversial. Emerging evidence suggests that pCRP can be dissociated into monomeric CRP (mCRP) that has major roles in host defenses and inflammation. Here, we discuss our current knowledge of the dissociation mechanisms of pCRP and summarize the stepwise conformational transition model to mCRP to elucidate how CRP dissociation contributes to proinflammatory activity. These discussions will evoke new understanding of this ancient protein.
Indexed as
Identifiers
31312858What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.