Evidence map›Paper›PMID 31312761›Full record

ArticleJACC. Basic to translational science2019

Malonyl CoA Decarboxylase Inhibition Improves Cardiac Function Post-Myocardial Infarction.

Wei Wang, Liyan Zhang, Pavan K Battiprolu, Arata Fukushima, Khanh Nguyen, Kenneth Milner, Abhishek Gupta, Tariq Altamimi, Nikole Byrne, Jun Mori and 13 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Basic to translational science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 63 citations in OpenAlex.

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  10. Article
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  13. Energy metabolism in health and diseases.Signal transduction and targeted therapy · 2025
    Review
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  16. Article
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  19. Advances in Metabolic Remodeling and Intervention Strategies in Heart Failure.Journal of cardiovascular translational research · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 2 institutions in 2 countries.

Wei WangCardiovascular Research Centre, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Liyan ZhangCardiovascular Research Centre, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Pavan K BattiproluAmgen, San Francisco, California.
Arata FukushimaCardiovascular Research Centre, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Khanh NguyenAmgen, San Francisco, California.
Kenneth MilnerCardiovascular Research Centre, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Abhishek GuptaCardiovascular Research Centre, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Tariq AltamimiCardiovascular Research Centre, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Nikole ByrneCardiovascular Research Centre, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Jun MoriCardiovascular Research Centre, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Osama Abo AlrobCardiovascular Research Centre, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Cory WaggCardiovascular Research Centre, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Natasha FillmoreCardiovascular Research Centre, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Shao-Hua WangDepartment of Cardiac Surgery, University of Alberta, Edmonton, Alberta, Canada.
Dongming M LiuAmgen, San Francisco, California.
Angela FuAmgen, San Francisco, California.
Jenny Yinglin LuAmgen, San Francisco, California.
Mary ChavesAmgen, San Francisco, California.
Alykhan MotaniAmgen, San Francisco, California.
John R UssherFaculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada.
Jeff D ReaganAmgen, San Francisco, California.
Jason R B DyckCardiovascular Research Centre, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Gary D LopaschukCardiovascular Research Centre, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
University of Alberta · CAAmgen (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alterations in cardiac energy metabolism after a myocardial infarction contribute to the severity of heart failure (HF). Although fatty acid oxidation can be impaired in HF, it is unclear if stimulating fatty acid oxidation is a desirable approach to treat HF. Both immediate and chronic malonyl coenzyme A decarboxylase inhibition, which decreases fatty acid oxidation, improved cardiac function through enhancing cardiac efficiency in a post-myocardial infarction rat that underwent permanent left anterior descending coronary artery ligation. The beneficial effects of MCD inhibition were attributed to a decrease in proton production due to an improved coupling between glycolysis and glucose oxidation.

Indexed as

ATGL, adipose triglyceride lipaseCPT1, carnitine palmitoyltransferase 1EF, ejection fractionfatty acid oxidationFOXO3, forkhead box O3glucose oxidationheart failureMCD, malonyl coenzyme A decarboxylaseMI, myocardial infarctionSERCA2, sarco(endo)plasmic reticulum Ca2+-ATPase 2SOD, superoxide dismutaseSPT, serine palmitoyltransferaseTAG, triacylglycerolTrx, thioredoxinuncoupling of glycolysis

Identifiers

PMID31312761
PMCPMC6609914
OpenAlexW2953473968

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.