Evidence map›Paper›PMID 31312753›Full record

ArticleJACC. Basic to translational science2019

Breastfeeding, Cellular Immune Activation, and Myocardial Recovery in Peripartum Cardiomyopathy.

Agnes Koczo, Amy Marino, Arun Jeyabalan, Uri Elkayam, Leslie T Cooper, James Fett, Joan Briller, Eileen Hsich, Lori Blauwet, Charles McTiernan and 4 more

Open access · goldAbstract read
In one paragraph

Article in JACC. Basic to translational science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 42 citations in OpenAlex.

  1. Review
  2. Article
  3. Lactation and cardiovascular health: A comprehensive review.American heart journal plus : cardiology research and practice · 2025
    Review
  4. Article
  5. Review
  6. Cathepsin-D and outcomes in peripartum cardiomyopathy: Results from IPAC.American heart journal plus : cardiology research and practice · 2025
    Article
  7. Article
  8. The inflammatory spectrum of cardiomyopathies.Frontiers in cardiovascular medicine · 2024
    Review
  9. Article
  10. Article
  11. Global Research Trends and Future Direction in Peripartum Cardiomyopathy: A Bibliometric Analysis.Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH · 2023
    Article
  12. Peripartum Cardiomyopathy: Risks Diagnosis and Management.Journal of multidisciplinary healthcare · 2023
    Review
  13. Maternal Heart Failure.Journal of the American Heart Association · 2021
    Review
  14. Peripartum cardiomyopathy.Heart failure reviews · 2021
    Review
  15. Article
  16. Article
  17. Article
  18. To Breastfeed or Not to Breastfeed With Peripartum Cardiomyopathy.JACC. Basic to translational science · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 1 country.

Agnes KoczoUniversity of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Amy MarinoUniversity of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Arun JeyabalanUniversity of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Uri ElkayamUniversity of Southern California, Los Angeles, California.
Leslie T CooperMayo Clinic, Jacksonville, Florida.
James FettUniversity of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Joan BrillerUniversity of Illinois, Chicago, Illinois.
Eileen HsichCleveland Clinic, Cleveland, Ohio.
Lori BlauwetMayo Clinic, Rochester, Minnesota.
Charles McTiernanUniversity of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Penelope A MorelUniversity of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Karen Hanley-YanezUniversity of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Dennis M McNamaraUniversity of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
IPAC Investigators
University of Pittsburgh Medical Center · USMayo Clinic · USCleveland Clinic · USJacksonville College · USUniversity of Southern California · USUniversity of Illinois Chicago · USUniversity of Illinois Urbana-Champaign · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The etiology of peripartum cardiomyopathy remains unknown. One hypothesis is that an increase in the 16-kDa form of prolactin is pathogenic and suggests that breastfeeding may worsen peripartum cardiomyopathy by increasing prolactin, while bromocriptine, which blocks prolactin release, may be therapeutic. An autoimmune etiology has also been proposed. The authors investigated the impact of breastfeeding on cellular immunity and myocardial recovery for women with peripartum cardiomyopathy in the IPAC (Investigations in Pregnancy Associated Cardiomyopathy) study. Women who breastfed had elevated prolactin, and prolactin levels correlated with elevations in CD8

Indexed as

BF, breastfeedingbreastfeedingimmune activationLVEF, left ventricular ejection fractionNBF, nonbreastfeedingperipartum cardiomyopathyPPCM, peripartum cardiomyopathy

Identifiers

PMID31312753
PMCPMC6609998
OpenAlexW2953605139

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.