Evidence map›Paper›PMID 31312635›Full record

ReviewMolecular neuropsychiatry2019

Imaging Biomarkers of the Neuroimmune System among Substance Use Disorders: A Systematic Review.

Eric A Woodcock, Ansel T Hillmer, Graeme F Mason, Kelly P Cosgrove

Open access · bronzeAbstract readReview
In one paragraph

Review in Molecular neuropsychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

  1. Trial
  2. Review
  3. Modafinil Improves Autism-like Behavior in Rats by Reducing Neuroinflammation.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2023
    Article
  4. Review
  5. [Cells · 2022
    Article
  6. Review
  7. Review
  8. Article
  9. The role of gut-immune-brain signaling in substance use disorders.International review of neurobiology · 2021
    Article
  10. Review
  11. Bidirectional Associations among Nicotine and Tobacco Smoke, NeuroHIV, and Antiretroviral Therapy.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020
    Review
  12. Article
  13. The Interplay between the Endocannabinoid System, Epilepsy and Cannabinoids.International journal of molecular sciences · 2019
    Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Eric A WoodcockDepartments of Psychiatry, and of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Connecticut, USA.
Ansel T HillmerDepartments of Psychiatry, and of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Connecticut, USA.
Graeme F MasonDepartments of Psychiatry, and of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Connecticut, USA.
Kelly P CosgroveDepartments of Psychiatry, and of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Connecticut, USA.
Yale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Neuroimaging Sciences Training ProgramT32DA022975 · NIDA · YALE UNIVERSITY · PI Graeme F Mason, Rajita Sinha · 2007 to 2026
$5.7M
Imaging Microglial Activation in PTSD with PETR01MH110674 · NIMH · YALE UNIVERSITY · PI COSGROVE, KELLY P., PIETRZAK, ROBERT H · 2017 to 2020
$3.1M
Multimodal Neuroimaging of Alcohol Withdrawal: The Role of Glutamate in Neural ReorganizationK01AA024788 · NIAAA · YALE UNIVERSITY · PI HILLMER, ANSEL · 2017 to 2021
$894k
Neuroimmune disruption in opioid use disorderR21DA047621 · NIDA · YALE UNIVERSITY · PI COSGROVE, KELLY P. · 2019 to 2020
$461k
Neuropharmacological investigation of frontostriatal network function and nicotine seeking behavior in current smokersF31DA040369 · NIDA · WAYNE STATE UNIVERSITY · PI WOODCOCK, ERIC ANDREW · 2016 to 2017
$61k
NCATS NIH HHS UL1 TR001863NIAAA NIH HHS K01 AA024788NIDA NIH HHS F31 DA040369NIDA NIH HHS R21 DA047621NIDA NIH HHS T32 DA022975NIMH NIH HHS R01 MH110674
6 · The paper itself

Abstract

There is tremendous interest in the role of the neuroimmune system and inflammatory processes in substance use disorders (SUDs). Imaging biomarkers of the neuroimmune system in vivo provide a vital translational bridge between preclinical and clinical research. Herein, we examine two imaging techniques that measure putative indices of the neuroimmune system and review their application among SUDs. Positron emission tomography (PET) imaging of 18 kDa translocator protein availability is a marker associated with microglia. Proton magnetic resonance spectroscopy quantification of

Indexed as

MicrogliaMyo-inositolNeuroinflammationSubstance use disordersTranslocator protein

Identifiers

PMID31312635
PMCPMC6597912
OpenAlexW2944081387

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.