ReviewChemistryOpen2019
Advances in the Physicochemical Profiling of Opioid Compounds of Therapeutic Interest.
Review in ChemistryOpen, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparison of Orthogonal Determination Methods of Acid/Base Constants with Meta-Analysis.International journal of molecular sciences · 2024Pooled it
- How Subtle Molecular Differences in the Morphinan Opioid Antagonists Affect Their Physicochemical and In Vitro ADME Properties.ACS medicinal chemistry letters · 2026Article
- Sublingual Administration for Pain Control: Pharmacology, Clinical Applications and Future Directions.CNS drugs · 2026Review
- Characterization of Opioid Agonist Morphine Derivatives with Emphasis on Medicinal Chemistry.ChemMedChem · 2025Article
- Opioids and pituitary function: expert opinion.Pituitary · 2022Review
- A Molecularly Imprinted Sol-Gel Electrochemical Sensor for Naloxone Determination.Nanomaterials (Basel, Switzerland) · 2021Article
- Trends in Poly Drug Use-associated Deaths based on Confirmed Analytical Toxicology Results in Tehran, Iran, in 2011-2016.Addiction & health · 2021Article
- Evaluation of Injectable Naloxone-Releasing Hydrogels.ACS applied bio materials · 2020Article
- Synthesis of Potential Haptens with Morphine Skeleton and Determination of Protonation Constants.Molecules (Basel, Switzerland) · 2020Article
- Pharmacokinetic and pharmacodynamic considerations in developing a response to the opioid epidemic.Expert opinion on drug metabolism & toxicology · 2020Review
- Advances in the Physicochemical Profiling of Opioid Compounds of Therapeutic Interest.ChemistryOpen · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review focuses on recent developments in the physicochemical profiling of morphine and other opioids. The acid-base properties and lipophilicity of these compounds is discussed at the microscopic, species-specific level. Examples are provided where this type of information can reveal the mechanism of pharmacokinetic processes at the submolecular level. The role of lipophilicity in quantitative structure-activity relationship (QSAR) studies of opioids is reviewed. The physicochemical properties and pharmacology of the main metabolites of morphine are also discussed. Recent studies indicate that the active metabolite morphine-6-glucuronide (M6G) can contribute to the analgesic activity of systemically administered morphine. The unexpectedly high lipophilicity of M6G partly accounts for its analgesic activity. When administered parenterally, another suspected minor metabolite, morphine-6-sulfate (M6S) has superior antinociceptive effects to those of morphine. However, because sulfate esters of morphine derivatives cannot cross the blood-brain barrier these esters may be good candidates to develop peripheral analgesic drugs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.