Evidence map›Paper›PMID 31312562›Full record

ArticleCureus2019

A Case Report of Human Herpesvirus-6 (HHV-6) Meningitis Masquerading as Idiopathic Intracranial Hypertension in an Immunocompetent Patient.

Hayden Z Smith, Richard Paguia, John Horne, Manasa Velagapudi

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Cureus, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Human herpesvirus 6 meningitis in an adult.Proceedings (Baylor University. Medical Center) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Hayden Z SmithInfectious Diseases, Creighton University Medical Center, Omaha, USA.
Richard PaguiaInfectious Diseases, Creighton University Medical Center, Omaha, USA.
John HorneInfectious Diseases, Creighton University Medical Center, Omaha, USA.
Manasa VelagapudiInfectious Diseases, Creighton University Medical Center, Omaha, USA.
CHI Health Creighton University Medical Center - Bergan Mercy · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present a case of a 32-year-old woman with signs and symptoms of idiopathic intracranial hypertension (IIH), but who, upon further investigation, was found to have human herpesvirus-6 (HHV-6) in both cerebrospinal fluid (CSF) and serum. This rare cause of meningitis in an immunocompetent individual and a relatively unique presentation is described along with a review of proper diagnostic workup and treatment. HHV-6 meningitis is commonly detected via molecular diagnostics and thus needs confirmatory testing of viral load of acellular compartments or viral serology. The reason for this added diagnostic step is due to the incorporation of the virus into the host DNA, leading to increased false-positive results on screening tests. In this case, proper diagnosis, treatment, and follow-up were pursued by following guidelines proposed in the literature of HHV-6 meningitis.

Indexed as

aseptic meningitisheadachehhv-6idiopathic intracranial hypertensionimmunocompetentnucleic acid amplification testingpseudotumor cerebriroseolaviral

Identifiers

PMID31312562
PMCPMC6623995
OpenAlexW2943993007

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.