Trial reportMolecular autism2019
Mechanisms underlying the EEG biomarker in Dup15q syndrome.
Trial report in Molecular autism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- Neural excitation/inhibition imbalance and neurodevelopmental pathology in human copy number variant syndromes: a systematic review.Journal of neurodevelopmental disorders · 2025Pooled it
- A randomized, double-blind, placebo-controlled phase II trial to explore the effects of a GABAJournal of neurodevelopmental disorders · 2022Trial
- Article
- Excess EEG beta-band oscillations in Dup15q syndrome correlate with clinical severity.Translational psychiatry · 2026Article
- RO4938581, a GABAMolecular psychiatry · 2026Article
- Tau pathology reprograms glucose metabolism to support cortical hyperexcitability, excitatory/inhibitory imbalance, and sleep loss.NPJ dementia · 2026Article
- Seminar in Epileptology: Normal awake and sleep patterns, interictal abnormalities, and ictal patterns on scalp EEG.Epileptic disorders : international epilepsy journal with videotape · 2025Review
- A direct comparison of laboratory and community EEG recordings for neurodevelopmental research.Scientific reports · 2025Article
- GABRA2-related encephalopathy: Identification of two phenotypes with distinctive electroclinical features.Epilepsia · 2025Article
- Exploring the neuromagnetic signatures of cognitive decline from mild cognitive impairment to Alzheimer's disease dementia.EBioMedicine · 2025Article
- GREEN: A lightweight architecture using learnable wavelets and Riemannian geometry for biomarker exploration with EEG signals.Patterns (New York, N.Y.) · 2025Article
- Resting state EEG in young children with Tuberous Sclerosis Complex: associations with medications and seizures.Journal of neurodevelopmental disorders · 2025Article
- Preclinical pharmacology of alogabat: a novel GABAFrontiers in pharmacology · 2025Article
- Cell-type-specific effects of autism-associated 15q duplication syndrome in the human brain.American journal of human genetics · 2024Article
- Machine learning of brain-specific biomarkers from EEG.EBioMedicine · 2024Article
- Sleep EEG signatures in mouse models of 15q11.2-13.1 duplication (Dup15q) syndrome.Journal of neurodevelopmental disorders · 2024Article
- Sex-biasing influence of autism-associatedScience advances · 2024Article
- Developmental trajectories of EEG aperiodic and periodic components in children 2-44 months of age.Nature communications · 2024Article
- Resting state EEG in young children with Tuberous Sclerosis Complex.Research square · 2024Article
- Developmental trajectories of EEG aperiodic and periodic components: Implications for understanding thalamocortical development during infancy.bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
13 authors at 5 institutions in 3 countries.
Funding
Abstract
Background: Duplications of 15q11.2-q13.1 (Dup15q syndrome), including the paternally imprinted gene Methods: To test the hypothesis that Results: Peak beta power was significantly increased in the reference cohort relative to TD controls. Midazolam administration recapitulated the beta EEG phenotype in healthy adults with a similar peak frequency in central channels ( Conclusions: Our results suggest a critical role for GABAergic transmission in the Dup15q syndrome beta EEG phenotype, which cannot be explained by
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.