ArticleAmerican journal of translational research2019
Therapeutic effect of low-intensity pulsed ultrasound on temporomandibular joint injury induced by chronic sleep deprivation in rats.
Article in American journal of translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- LIPUS promotes osteogenic differentiation of rat BMSCs and osseointegration of dental implants by regulating ITGA11 and focal adhesion pathway.BMC oral health · 2025Article
- Low-Intensity Pulsed Ultrasound: A Physical Stimulus with Immunomodulatory and Anti-inflammatory Potential.Annals of biomedical engineering · 2024Review
- Low-intensity pulsed ultrasound promotes skeletal muscle regeneration via modulating the inflammatory immune microenvironment.International journal of biological sciences · 2023Article
- Osteoarthritis is positively associated with self-reported sleep trouble in older adults.Aging clinical and experimental research · 2022Article
- Intraperitoneal ozone injection prevents REM sleep deprivation - induced spatial learning and memory deficits by suppressing the expression ofIranian journal of basic medical sciences · 2022Article
- Animal Models of Temporomandibular Joint Osteoarthritis: Classification and Selection.Frontiers in physiology · 2022Review
- CYT387, a JAK-Specific Inhibitor Impedes Osteoclast Activity and Oophorectomy-Induced OsteoporosisFrontiers in pharmacology · 2022Article
- Effectiveness and Mechanisms of Low-Intensity Pulsed Ultrasound on Osseointegration of Dental Implants and Biological Functions of Bone Marrow Mesenchymal Stem Cells.Stem cells international · 2022Review
- The therapeutic effects of low-intensity pulsed ultrasound in musculoskeletal soft tissue injuries: Focusing on the molecular mechanism.Frontiers in bioengineering and biotechnology · 2022Review
- Small extracellular vesicles in combination with sleep-related circRNA3503: A targeted therapeutic agent with injectable thermosensitive hydrogel to prevent osteoarthritis.Bioactive materials · 2021Article
- The Attenuating Effect of Low-Intensity Pulsed Ultrasound on Hypoxia-Induced Rat Chondrocyte Damage in TMJ Osteoarthritis Based on TMT Labeling Quantitative Proteomic Analysis.Frontiers in pharmacology · 2021Article
- Comparison of Role of Hand and Wrist Ultrasound in Diagnosis of Subclinical Synovitis in Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis: A Retrospective, Single-Center Study.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Effects of collimated and focused low-intensity pulsed ultrasound stimulation on the mandible repair in rabbits.Annals of translational medicine · 2020Article
- The Optimal Regimen for the Treatment of Temporomandibular Joint Injury Using Low-Intensity Pulsed Ultrasound in Rats with Chronic Sleep Deprivation.BioMed research international · 2020Article
- Low-Intensity Pulsed Ultrasound Alleviates Hypoxia-Induced Chondrocyte Damage in Temporomandibular Disorders by Modulating the Hypoxia-Inducible Factor Pathway.Frontiers in pharmacology · 2020Article
- Effect of therapeutic ultrasound on the quadriceps muscle injury in rats - evaluation of oxidative stress and inflammatory process.American journal of translational research · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Low-intensity pulsed ultrasound (LIPUS) treatment is an emerging physical therapy for treating bone, nerve, and muscle disorders. However, there have been no reports on the effectiveness of LIPUS for the treatment of temporomandibular joint injury, and the mechanisms of LIPUS remain unclear. The purpose of this study was to examine the therapeutic effects of LIPUS on temporomandibular joint injury in rats subjected to chronic sleep deprivation (CSD). In this study, after 2 weeks of chronic sleep deprivation in rats, the condylar cartilage exhibited rough surfaces, with a disorganized arrangement and partial sloughing of collagen fibers, decreased proliferation of chondrocytes, increased osteoclast activity in the calcified cartilage layer, and increased ratios of MMP-3/TIMP-1 and RANKL/OPG expression. After 4 weeks of LIPUS intervention in rats, the condylar cartilage displayed prominent reductions in these pathological changes, including noticeable repair of the injured cartilage structure, increased chondrocyte proliferation, a reduced number of osteoclasts, and marked reductions in the expression ratios of MMP-3/TIMP-1 and RANKL/OPG. These results demonstrated that LIPUS can effectively inhibit CSD-induced injury to condylar cartilage in rats. The therapeutic mechanism of LIPUS may involve promoting the repair function of chondrocytes and reducing the expression ratios of MMP-3/TIMP-1 and RANKL/OPG in condylar tissue, thus inhibiting the cleavage activity of MMP-3 on the condylar cartilage matrix and inhibiting osteoclast activation.
Indexed as
Identifiers
31312347PMC6614610W2994636686What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.