Effect of intra-articular hyaluronan injection on inflammation and bone remodeling in the epiphyses and metaphyses of the knee in a murine model of joint injury.

Quan Shen, Jun Li, Deva Chan, John D Sandy, Jun Takeuchi, Ryan D Ross, Anna Plaas

Abstract read

In one paragraph

Article in American journal of translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

In vivo impact on rabbit subchondral bone of viscosupplementation with a hyaluronic acid antioxidant conjugate.BMC musculoskeletal disorders · 2024
Article
Mechanobiology of Hyaluronan: Connecting Biomechanics and Bioactivity in Musculoskeletal Tissues.Annual review of biomedical engineering · 2024
Review
An injectable copolymer of fatty acids (ARA 3000 BETA) as a promising treatment for osteoarthritis.Scientific reports · 2023
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Quan ShenDepartment of Internal Medicine (Rheumatology), Rush University Medical Center Chicago, IL, USA.

Jun LiDepartment of Internal Medicine (Rheumatology), Rush University Medical Center Chicago, IL, USA.

Deva ChanDepartment of Biomedical Engineering Rensselaer Polytechnic Institute Troy, NY, USA.

John D SandyDepartment of Orthopedic Surgery, Rush University Medical Center Chicago, IL, USA.

Jun TakeuchiMedical Science Liaison Unit, Seikagaku Corporation Tokyo, Japan.

Ryan D RossDepartment of Orthopedic Surgery, Rush University Medical Center Chicago, IL, USA.

Anna PlaasDepartment of Internal Medicine (Rheumatology), Rush University Medical Center Chicago, IL, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The TTR (transforming growth factor β1 (TGFβ1) injection with treadmill running) model of murine joint injury was used to examine effects of intra-articular Hyaluronan (IA HA) on the metabolism of subchondral bone. HA was injected 24 h after TGFβ1 injection and its effects on the mRNA of 80 genes in the Nfkb pathway, and bone remodeling genes,

Indexed as

bonehyaluronaninflammationmacrophagesNfkbTGFb1

Identifiers

PMID31312344

PMCPMC6614662

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.