Evidence map›Paper›PMID 31312200›Full record

ArticleFrontiers in immunology2019

CRTAM Protects Against Intestinal Dysbiosis During Pathogenic Parasitic Infection by Enabling Th17 Maturation.

Luisa Cervantes-Barragan, Victor S Cortez, Qiuling Wang, Keely G McDonald, Jiani N Chai, Blanda Di Luccia, Susan Gilfillan, Chyi-Song Hsieh, Rodney D Newberry, L David Sibley and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. CircRNA and miRNA expression analysis in livers of mice withFrontiers in cellular and infection microbiology · 2022
    Article
  7. Changes of gut microbiota structure in rats infected withFrontiers in cellular and infection microbiology · 2022
    Article
  8. Review
  9. ChronicProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  10. A NovelFrontiers in microbiology · 2020
    Article
  11. From Initiators to Effectors: Roadmap Through the Intestine During Encounter ofFrontiers in cellular and infection microbiology · 2020
    Review
  12. Immune response against toxoplasmosis-some recent updates RH:International journal of immunopathology and pharmacology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Luisa Cervantes-BarraganDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, United States.
Victor S CortezDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, United States.
Qiuling WangDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, United States.
Keely G McDonaldDivision of Gastroenterology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, United States.
Jiani N ChaiDivision of Rheumatology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, United States.
Blanda Di LucciaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, United States.
Susan GilfillanDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, United States.
Chyi-Song HsiehDivision of Rheumatology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, United States.
Rodney D NewberryDivision of Gastroenterology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, United States.
L David SibleyDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, United States.
Marco ColonnaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, United States.
Washington University in St. Louis · US

Funding

Mucosal Immune Defense Mechanisms of the Urinary BladderU01AI095542 · NIAID · WASHINGTON UNIVERSITY · PI COLONNA, MARCO, HULTGREN, SCOTT J. · 2011 to 2020
$9.8M
Molecular Basis of Human ToxoplasmosisR01AI118426 · NIAID · WASHINGTON UNIVERSITY · PI SIBLEY, L. DAVID · 2015 to 2024
$6.0M
GOBLET CELLS IN INTESTINAL IMMUNE HOMEOSTATSISR01DK097317 · NIDDK · WASHINGTON UNIVERSITY · PI NEWBERRY, RODNEY D · 2012 to 2025
$5.6M
The Role of Route of Entry by Bacterial Antigens on Colonic T Cell ResponsesR01AI136515 · NIAID · WASHINGTON UNIVERSITY · PI HSIEH, CHYI S, NEWBERRY, RODNEY D · 2018 to 2022
$2.8M
CRTAM-CADM1 INTERACTION IN THE BIOLOGY OF GUT LYMPHOCYTESR01DK103039 · NIDDK · WASHINGTON UNIVERSITY · PI COLONNA, MARCO · 2015 to 2018
$1.4M
NIAID NIH HHS R01 AI118426NIAID NIH HHS R01 AI136515NIAID NIH HHS U01 AI095542NIDDK NIH HHS R01 DK097317NIDDK NIH HHS R01 DK103039
6 · The paper itself

Abstract

The gastrointestinal tract hosts the largest collection of commensal microbes in the body. Infections at this site can cause significant perturbations in the microbiota, known as dysbiosis, that facilitate the expansion of pathobionts, and can elicit inappropriate immune responses that impair the intestinal barrier function. Dysbiosis typically occurs during intestinal infection with

Indexed as

alpha-DefensinsAnimalsbeta-DefensinsCell DifferentiationDysbiosisFemaleGastrointestinal MicrobiomeImmunoglobulinsInterleukin-17Intestinal MucosaMaleMiceMice, Inbred C57BLMice, KnockoutTh17 CellsToxoplasmaalpha-Defensinsbeta-Defensinsclass-I restricted T cell-associated moleculeIl17a protein, mouseImmunoglobulinsInterleukin-17CRTAMinterleukin 17mucosal immunityT cellsToxoplasma gondii

Identifiers

PMID31312200
PMCPMC6614434
OpenAlexW2955128276

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.