ReviewReproductive medicine and biology2019
Reproductive neuroendocrinology of mammalian gonadotropin-inhibitory hormone.
Review in Reproductive medicine and biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- The effect of two types of exercise conditioning on hypothalamic corticotropin-releasing hormone (CRH) and gonadotropin-releasing hormone (GNRH) gene expression response to acute noise stress in rats.BMC research notes · 2025Article
- Huatan Tongmai Yin regulates RFRP-3 to intervene in the "microbe-gut-HPO axis" to treat PCOS-IR rats.American journal of translational research · 2025Article
- Chemogenetic Activation of RFRP Neurons Reduces LH Pulse Frequency in Female but not Male Mice.Journal of the Endocrine Society · 2024Article
- Reproduction of Awassi and Hamdani Sheep Is Associated With a Novel Missense SNP (p.24Ile>Thr) of theBioinformatics and biology insights · 2024Article
- Effects of gonadotropin-inhibitory hormone on testicular development and reproduction-related gene expression in roosters.Animal biotechnology · 2023Article
- The Corticosterone-Glucocorticoid Receptor-AP1/CREB Axis Inhibits the Luteinizing Hormone Receptor Expression in Mouse Granulosa Cells.International journal of molecular sciences · 2022Article
- Signatures of adaptive evolution in platyrrhine primate genomes.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Possible Role of GnIH as a Novel Link between Hyperphagia-Induced Obesity-Related Metabolic Derangements and Hypogonadism in Male Mice.International journal of molecular sciences · 2022Article
- RF-amide related peptide-3 (RFRP-3): a novel neuroendocrine regulator of energy homeostasis, metabolism, and reproduction.Molecular biology reports · 2021Review
- Modeling circadian regulation of ovulation timing: age-related disruption of estrous cyclicity.Scientific reports · 2020Article
- Effect of Inflammation on Female Gonadotropin-Releasing Hormone (GnRH) Neurons: Mechanisms and Consequences.International journal of molecular sciences · 2020Review
- Reproductive neuroendocrinology of mammalian gonadotropin-inhibitory hormone.Reproductive medicine and biology · 2019Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGonadotropin-inhibitory hormone (GnIH) was discovered in the Japanese quail brain in 2000 as a hypothalamic neuropeptide that suppresses luteinizing hormone release from cultured quail anterior pituitary.
methodsThe authors investigated the existence of mammalian orthologous peptides to GnIH and their physiological functions in the following 19 years of research. MAIN
findingsMammals have orthologous peptide to GnIH, often described RFamide-related peptide, expressed in the hypothalamus and gonads. Mammalian GnIH may also suppress gonadotropin synthesis and release by suppressing gonadotropin-releasing hormone (GnRH) synthesis and release in addition to directly suppressing gonadotropin synthesis and release from the pituitary. Mammalian GnIH may also suppress kisspeptin, a stimulator of GnRH, release. Mammalian GnIH is also expressed in the testis and ovary and suppresses gametogenesis and sex steroid production acting in an autocrine/paracrine manner. Thus, mammalian GnIH may act at all levels of the hypothalamic-pituitary-gonadal axis to suppress reproduction. GnIH may be involved in the regulation of puberty, estrous or menstrual cycle, seasonal reproduction, and stress responses.
conclusionStudies suggest that mammalian GnIH is an important neuroendocrine suppressor of reproduction in mammals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.