ArticleNature communications2019
Cerebellar disruption impairs working memory during evidence accumulation.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Purkinje Cells in Crus I and II Encode the Visual Stimulus and the Impending Choice as Monkeys Learn a Reinforcement-Based Visuomotor Association Task.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Cerebellar Functional Alterations During Executive Functioning Are Associated With General Psychopathology in a Cross-Diagnostic Sample.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Cerebellar microcircuits enable robust evidence-based decisions through cortico-cerebellar coupling.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Light-activated insulin receptor modulates neuronal plasticity and cerebellar-driven behavior.iScience · 2026Article
- The Drp1-CoQ10-Coa6-ETC axis represents a therapeutic potential for working memory impairment caused by neuronal mitochondrial dysfunction.Translational neurodegeneration · 2026Article
- Cerebellar acceleration of learning in an evidence-accumulation task.Cell reports · 2026Article
- Cognitive training shapes brain plasticity and schematic representations.Behavioral and brain functions : BBF · 2025Review
- Autism Spectrum Disorder: The Cerebellum, Genes, and Pathways.Neurology international · 2025Review
- Striatal and cerebellar interactions during reward-based motor performance.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Cerebellar and subcortical contributions to working memory manipulation.Communications biology · 2025Article
- Common and rare variant analyses implicate late-infancy cerebellar development and immune genes in ADHD.Journal of neurodevelopmental disorders · 2025Article
- Striatal and cerebellar interactions during reward-based motor performance.bioRxiv : the preprint server for biology · 2025Article
- Encoding of cerebellar dentate neuron activity during visual attention in rhesus macaques.eLife · 2025Article
- Cerebellar-driven cortical dynamics can enable task acquisition, switching and consolidation.Nature communications · 2024Article
- Aberrant outputs of cerebellar nuclei and targeted rescue of social deficits in an autism mouse model.Protein & cell · 2024Article
- Is working memory domain-general or domain-specific?Trends in cognitive sciences · 2024Review
- A cerebro-cerebellar network for learning visuomotor associations.Nature communications · 2024Article
- A canonical polyadic tensor basis for fast Bayesian estimation of multi-subject brain activation patterns.Frontiers in neuroinformatics · 2024Article
- Automating licking bias correction in a two-choice delayed match-to-sample task to accelerate learning.Scientific reports · 2023Article
- Gender and cytoarchitecture differences: Functional connectivity of the hippocampal sub-regions.Heliyon · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
To select actions based on sensory evidence, animals must create and manipulate representations of stimulus information in memory. Here we report that during accumulation of somatosensory evidence, optogenetic manipulation of cerebellar Purkinje cells reduces the accuracy of subsequent memory-guided decisions and causes mice to downweight prior information. Behavioral deficits are consistent with the addition of noise and leak to the evidence accumulation process. We conclude that the cerebellum can influence the accurate maintenance of working memory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.