Evidence map›Paper›PMID 31311885›Full record

ArticlemBio2019

RocA Binds CsrS To Modulate CsrRS-Mediated Gene Regulation in Group A

Nicola N Lynskey, Jorge J Velarde, Meredith B Finn, Simon L Dove, Michael R Wessels

Open access · goldAbstract read
In one paragraph

Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
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  5. Reversal of Azithromycin Resistance inFrontiers in veterinary science · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Nicola N LynskeyDivision of Infectious Diseases, Boston Children's Hospital, Boston, Massachusetts, USA Nicola.Lynskey@childrens.harvard.edu.
Jorge J VelardeDivision of Infectious Diseases, Boston Children's Hospital, Boston, Massachusetts, USA.
Meredith B FinnDivision of Infectious Diseases, Boston Children's Hospital, Boston, Massachusetts, USA.
Simon L DoveDivision of Infectious Diseases, Boston Children's Hospital, Boston, Massachusetts, USA.
Michael R WesselsDivision of Infectious Diseases, Boston Children's Hospital, Boston, Massachusetts, USA.
Boston Children's Hospital · USHarvard University · US

Funding

IMMUNE RESPONSE TO THE GROUP A STREPTOCOCCAL CAPSULER01AI029952 · NIAID · CHILDREN'S HOSPITAL BOSTON · PI WESSELS, MICHAEL R · 1991 to 2019
$5.6M
Structure and Function Studies of LL-37 Binding to CsrS of Group A StreptococcusK08AI112823 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI VELARDE, JORGE J · 2016 to 2020
$939k
NIAID NIH HHS K08 AI112823NIAID NIH HHS R01 AI029952
6 · The paper itself

Abstract

The orphan regulator RocA plays a critical role in the colonization and pathogenesis of the obligate human pathogen group A

Indexed as

Gene Expression Regulation, BacterialBacterial ProteinsHumansPhosphorylationProtein BindingProtein Interaction Domains and MotifsProtein KinasesProtein MultimerizationRepressor ProteinsStreptococcal InfectionsStreptococcus pyogenesTrans-ActivatorsVirulenceBacterial ProteinsCsrR protein, Streptococcus pyogenesCsrS protein, bacteriaProtein KinasesRepressor ProteinsRocA protein, Streptococcus pyogenesTrans-Activatorsgene regulationpathogenesisregulatory proteinsStreptococcus pyogenesvirulence

Identifiers

PMID31311885
PMCPMC6635533
OpenAlexW2961122797

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.