Reply to Nikaido: The pyruvate cycle provides respiratory energy and potentiates aminoglycosides to kill multidrug-resistant bacteria.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

2 citing papers in PubMed.

1. Pyruvate Abundance Confounds Aminoglycoside Killing of Multidrug-Resistant Bacteria via Glutathione Metabolism.Research (Washington, D.C.) · 2024
   Article
2. Alanine-mediated P cycle boosting enhances the killing efficiency of kasugamycin on antibiotic-resistantFrontiers in microbiology · 2023
   Article

Corrections and comments

• Comment on
  Pyruvate cycle increases aminoglycoside efficacy and provides respiratory energy in bacteria.2018
• Comment on
  P cycle cannot be a general mechanism for energy production, and it does not sensitize bacteria toward aminoglycosides.2019

Authors and funding

8 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as