Evidence map›Paper›PMID 31311865›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

The TGFβ type I receptor TGFβRI functions as an inhibitor of BMP signaling in cartilage.

Weiguang Wang, Hyelim Chun, Jongseung Baek, Joshua Elyahu Sadik, Anna Shirazyan, Peyman Razavi, Noah Lopez, Karen M Lyons

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
  3. Context-dependent TGFβ family signalling in cell fate regulation.Nature reviews. Molecular cell biology · 2023
    Review
  4. Osteoarthritis: pathogenic signaling pathways and therapeutic targets.Signal transduction and targeted therapy · 2023
    Review
  5. Review
  6. Overexpression of Wild-Type ACVR1 in Fibrodysplasia Ossificans Progressiva Mice Rescues Perinatal Lethality and Inhibits Heterotopic Ossification.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. SMAD4 Feedback Activates the Canonical TGF-β Family Signaling Pathways.International journal of molecular sciences · 2021
    Article
  12. Article
  13. Article
  14. Article
  15. Fluid shear stress generates a unique signaling response by activating multiple TGFβ family type I receptors in osteocytes.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
    Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Weiguang WangDepartment of Orthopaedic Surgery, University of California, Los Angeles, CA 90095.
Hyelim ChunDepartment of Molecular Cell and Developmental Biology, University of California, Los Angeles, CA 90095.
Jongseung BaekDepartment of Orthopaedic Surgery, University of California, Los Angeles, CA 90095.
Joshua Elyahu SadikDepartment of Molecular Cell and Developmental Biology, University of California, Los Angeles, CA 90095.
Anna ShirazyanDepartment of Molecular Cell and Developmental Biology, University of California, Los Angeles, CA 90095.
Peyman RazaviDepartment of Molecular Cell and Developmental Biology, University of California, Los Angeles, CA 90095.
Noah LopezDepartment of Molecular Cell and Developmental Biology, University of California, Los Angeles, CA 90095.
Karen M LyonsDepartment of Orthopaedic Surgery, University of California, Los Angeles, CA 90095; klyons@mednet.ucla.edu.
University of California, Los Angeles · USOrthopaedic Hospital · US

Funding

BMPS IN SKELETAL GROWTH AND OSTEOGENIC DIFFERENTIATIONR01AR044528 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LYONS, KAREN M. · 1998 to 2017
$5.2M
Regenerative Musculoskeletal Medicine Training ProgramT32AR059033 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI John S Adams, Nicholas M. Bernthal · 2011 to 2026
$4.8M
Title: BMP/TGFbeta crosstalk in cartilage maintenance and osteoarthritisR01AR073793 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LYONS, KAREN M. · 2018 to 2023
$1.7M
NIAMS NIH HHS R01 AR044528NIAMS NIH HHS R01 AR073793NIAMS NIH HHS T32 AR059033
6 · The paper itself

Abstract

The type I TGFβ receptor TGFβRI (encoded by

Indexed as

Signal TransductionActivin Receptors, Type IIAnimalsCartilageGrowth Differentiation Factor 2MiceMice, KnockoutReceptor, Transforming Growth Factor-beta Type IActivin Receptors, Type IIactivin receptor type II-BAcvrl1 protein, mouseGdf2 protein, mouseGrowth Differentiation Factor 2Receptor, Transforming Growth Factor-beta Type ITgfbr1 protein, mouseALK1ALK5BMPcartilageTGFβ

Identifiers

PMID31311865
PMCPMC6681752
OpenAlexW2956207039

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.