Evidence map›Paper›PMID 31311842›Full record

ArticleNeurology2019

Impulse control disorders in Parkinson disease and RBD: A longitudinal study of severity.

Fahd Baig, Mark J Kelly, Michael A Lawton, Claudio Ruffmann, Michal Rolinski, Johannes C Klein, Thomas Barber, Christine Lo, Yoav Ben-Shlomo, David Okai and 1 more

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In one paragraph

Article in Neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Risk factors and outcome of dopamine dysregulation syndrome in a large Chinese Parkinson's disease cohort.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  7. Review
  8. Article
  9. Sense of agency and decision making.Frontiers in psychology · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Behavioral disorders in Parkinson disease: current view.Journal of neural transmission (Vienna, Austria : 1996) · 2025
    Review
  14. Review
  15. Review
  16. Article
  17. Impulse control disorders in Parkinson's disease: a retrospective analysis of 1824 patients in a 12-year period.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Fahd BaigFrom the Oxford Parkinson's Disease Centre (F.B., M.J.K., M.A.L., C.R., M.R., J.C.K., T.B., C.L., Y.B.-S., D.O., M.T.H.), and Nuffield Department of Clinical Neurosciences (F.B., M.J.K.), University of Oxford; Population Health Sciences (M.A.L., Y.B.-S.) and Translational Health Sciences (M.R.), University of Bristol; and Department of Psychological Medicine (D.O.), Oxford University Hospitals NHS Trust, UK.ORCID 0000-0002-3315-2698
Mark J KellyFrom the Oxford Parkinson's Disease Centre (F.B., M.J.K., M.A.L., C.R., M.R., J.C.K., T.B., C.L., Y.B.-S., D.O., M.T.H.), and Nuffield Department of Clinical Neurosciences (F.B., M.J.K.), University of Oxford; Population Health Sciences (M.A.L., Y.B.-S.) and Translational Health Sciences (M.R.), University of Bristol; and Department of Psychological Medicine (D.O.), Oxford University Hospitals NHS Trust, UK.
Michael A LawtonFrom the Oxford Parkinson's Disease Centre (F.B., M.J.K., M.A.L., C.R., M.R., J.C.K., T.B., C.L., Y.B.-S., D.O., M.T.H.), and Nuffield Department of Clinical Neurosciences (F.B., M.J.K.), University of Oxford; Population Health Sciences (M.A.L., Y.B.-S.) and Translational Health Sciences (M.R.), University of Bristol; and Department of Psychological Medicine (D.O.), Oxford University Hospitals NHS Trust, UK.
Claudio RuffmannFrom the Oxford Parkinson's Disease Centre (F.B., M.J.K., M.A.L., C.R., M.R., J.C.K., T.B., C.L., Y.B.-S., D.O., M.T.H.), and Nuffield Department of Clinical Neurosciences (F.B., M.J.K.), University of Oxford; Population Health Sciences (M.A.L., Y.B.-S.) and Translational Health Sciences (M.R.), University of Bristol; and Department of Psychological Medicine (D.O.), Oxford University Hospitals NHS Trust, UK.
Michal RolinskiFrom the Oxford Parkinson's Disease Centre (F.B., M.J.K., M.A.L., C.R., M.R., J.C.K., T.B., C.L., Y.B.-S., D.O., M.T.H.), and Nuffield Department of Clinical Neurosciences (F.B., M.J.K.), University of Oxford; Population Health Sciences (M.A.L., Y.B.-S.) and Translational Health Sciences (M.R.), University of Bristol; and Department of Psychological Medicine (D.O.), Oxford University Hospitals NHS Trust, UK.
Johannes C KleinFrom the Oxford Parkinson's Disease Centre (F.B., M.J.K., M.A.L., C.R., M.R., J.C.K., T.B., C.L., Y.B.-S., D.O., M.T.H.), and Nuffield Department of Clinical Neurosciences (F.B., M.J.K.), University of Oxford; Population Health Sciences (M.A.L., Y.B.-S.) and Translational Health Sciences (M.R.), University of Bristol; and Department of Psychological Medicine (D.O.), Oxford University Hospitals NHS Trust, UK.
Thomas BarberFrom the Oxford Parkinson's Disease Centre (F.B., M.J.K., M.A.L., C.R., M.R., J.C.K., T.B., C.L., Y.B.-S., D.O., M.T.H.), and Nuffield Department of Clinical Neurosciences (F.B., M.J.K.), University of Oxford; Population Health Sciences (M.A.L., Y.B.-S.) and Translational Health Sciences (M.R.), University of Bristol; and Department of Psychological Medicine (D.O.), Oxford University Hospitals NHS Trust, UK.
Christine LoFrom the Oxford Parkinson's Disease Centre (F.B., M.J.K., M.A.L., C.R., M.R., J.C.K., T.B., C.L., Y.B.-S., D.O., M.T.H.), and Nuffield Department of Clinical Neurosciences (F.B., M.J.K.), University of Oxford; Population Health Sciences (M.A.L., Y.B.-S.) and Translational Health Sciences (M.R.), University of Bristol; and Department of Psychological Medicine (D.O.), Oxford University Hospitals NHS Trust, UK.
Yoav Ben-ShlomoFrom the Oxford Parkinson's Disease Centre (F.B., M.J.K., M.A.L., C.R., M.R., J.C.K., T.B., C.L., Y.B.-S., D.O., M.T.H.), and Nuffield Department of Clinical Neurosciences (F.B., M.J.K.), University of Oxford; Population Health Sciences (M.A.L., Y.B.-S.) and Translational Health Sciences (M.R.), University of Bristol; and Department of Psychological Medicine (D.O.), Oxford University Hospitals NHS Trust, UK.
David OkaiFrom the Oxford Parkinson's Disease Centre (F.B., M.J.K., M.A.L., C.R., M.R., J.C.K., T.B., C.L., Y.B.-S., D.O., M.T.H.), and Nuffield Department of Clinical Neurosciences (F.B., M.J.K.), University of Oxford; Population Health Sciences (M.A.L., Y.B.-S.) and Translational Health Sciences (M.R.), University of Bristol; and Department of Psychological Medicine (D.O.), Oxford University Hospitals NHS Trust, UK.
Michele T HuFrom the Oxford Parkinson's Disease Centre (F.B., M.J.K., M.A.L., C.R., M.R., J.C.K., T.B., C.L., Y.B.-S., D.O., M.T.H.), and Nuffield Department of Clinical Neurosciences (F.B., M.J.K.), University of Oxford; Population Health Sciences (M.A.L., Y.B.-S.) and Translational Health Sciences (M.R.), University of Bristol; and Department of Psychological Medicine (D.O.), Oxford University Hospitals NHS Trust, UK. Michele.hu@ndcn.ox.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo describe the prevalence, natural history, and risk factors for impulse control behaviors (ICBs) among people with Parkinson disease (PD), those with REM sleep behavior disorder (RBD), and controls.

methodsParticipants with early PD (within 3.5 years of diagnosis), those with RBD, and controls were clinically phenotyped and screened for ICBs longitudinally (with the Questionnaire for Impulsivity in Parkinson's Disease). ICB-positive individuals were invited for a semistructured interview, repeated 1 year later. The severity of the ICB was assessed with the Parkinson's Impulse Control Scale. Multiple imputation and regression models were used to estimate ICB prevalence and associations.

resultsData from 921 cases of PD at baseline, 768 cases at 18 months, and 531 cases at 36 months were included, with 21% to 25% screening positive for ICBs at each visit. Interviews of ICB screen-positive individuals revealed that 10% met formal criteria for impulse control disorders (ICD), while 33% had subsyndromal ICD (ICB symptoms without reaching the formal diagnostic criteria for ICD). When these data were combined through the use of multiple imputation, the prevalence of PD-ICB was estimated at 19.1% (95% confidence interval 10.1-28.2). On follow-up, 24% of cases of subsyndromal ICD had developed full symptoms of an ICD. PD-ICD was associated with dopamine agonist use, motor complications, and apathy but not PD-RBD. ICD prevalence in the RBD group (1%) was similar to that in controls (0.7%).

conclusionsICBs occur in 19.1% of patients with early PD, many persisting or worsening over time. RBD is not associated with increased ICD risk. Psychosocial drivers, including mood and support networks, affect severity.

Indexed as

AdultAgedAged, 80 and overCase-Control StudiesDisruptive, Impulse Control, and Conduct DisordersDopamine AgonistsFemaleHumansImpulsive BehaviorLongitudinal StudiesMaleMiddle AgedParkinson DiseaseREM Sleep Behavior DisorderRisk FactorsDopamine Agonists

Identifiers

PMID31311842
PMCPMC6715510

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.