Evidence map›Paper›PMID 31311808›Full record

ArticleCancer research2019

A Near-Infrared Phosphorescent Nanoprobe Enables Quantitative, Longitudinal Imaging of Tumor Hypoxia Dynamics during Radiotherapy.

Xianchuang Zheng, Liyang Cui, Min Chen, Luis A Soto, Edward E Graves, Jianghong Rao

Abstract read
In one paragraph

Article in Cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 32 citations in OpenAlex.

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  11. Real-time optical oximetry during FLASH radiotherapy using a phosphorescent nanoprobe.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2022
    Article
  12. Article
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  14. Oxygen-Sensitive MRI: A Predictive Imaging Biomarker for Tumor Radiation Response?International journal of radiation oncology, biology, physics · 2021
    Article
  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xianchuang ZhengDepartment of Radiology, Molecular Imaging Program at Stanford, School of Medicine, Stanford University, Stanford, California.
Liyang CuiDepartment of Radiology, Molecular Imaging Program at Stanford, School of Medicine, Stanford University, Stanford, California.
Min ChenDepartment of Radiology, Molecular Imaging Program at Stanford, School of Medicine, Stanford University, Stanford, California.ORCID 0000-0002-6488-455X
Luis A SotoDepartment of Radiation Oncology, Molecular Imaging Program at Stanford, School of Medicine, Stanford University, Stanford, California.
Edward E GravesDepartment of Radiation Oncology, Molecular Imaging Program at Stanford, School of Medicine, Stanford University, Stanford, California.
Jianghong RaoDepartment of Radiology, Molecular Imaging Program at Stanford, School of Medicine, Stanford University, Stanford, California. jrao@stanford.edu.
Stanford Medicine · US

Funding

Translational Oncology Research Program (Project-005)P30CA124435 · NCI · STANFORD UNIVERSITY · PI Vittorio Sebastiano · 2007 to 2026
$71.4M
Leveraging innovative technologies in basic and clinical cancer researchT32CA009302 · NCI · STANFORD UNIVERSITY · PI LAURA D ATTARDI, Aaron M Newman · 1985 to 2026
$19.1M
Nano Characterization and Nano Fabrication CoreU54CA199075 · NCI · STANFORD UNIVERSITY · PI SINCLAIR, ROBERT · 2015 to 2019
$9.6M
Noninvasive deep-tissue single-cell imaging and nanoprobe developmentR01GM128089 · NIGMS · STANFORD UNIVERSITY · PI CHU, STEVEN, RAO, JIANGHONG · 2018 to 2021
$2.2M
Small Animal Radiation Research Platform @ StanfordS10OD018208 · OD · STANFORD UNIVERSITY · PI GRAVES, EDWARD E. · 2014 to 2014
$600k
NCI NIH HHS P30 CA124435NCI NIH HHS T32 CA009302NCI NIH HHS U54 CA199075NIGMS NIH HHS R01 GM128089NIH HHS S10 OD018208
6 · The paper itself

Abstract

Hypoxia plays a key role in tumor resistance to radiotherapy. It is important to study hypoxia dynamics during radiotherapy to improve treatment planning and prognosis. Here, we describe a luminescent nanoprobe, composed of a fluorescent semiconducting polymer and palladium complex, for quantitative longitudinal imaging of tumor hypoxia dynamics during radiotherapy. The nanoprobe was designed to provide high sensitivity and reversible response for the subtle change in hypoxia over a narrow range (0-30 mmHg O

Indexed as

AnimalsDose Fractionation, RadiationFemaleHumansHypoxiaImage Processing, Computer-AssistedLuminescenceLuminescent AgentsMiceMice, NudeMolecular ProbesNanoparticlesNeoplasmsSpectroscopy, Near-InfraredTumor Cells, CulturedXenograft Model Antitumor AssaysLuminescent AgentsMolecular Probes

Identifiers

PMID31311808
PMCPMC6744984
OpenAlexW2956377452

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.