ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2019
Atypical Dorsolateral Prefrontal Activity in Female Adolescents With Conduct Disorder During Effortful Emotion Regulation.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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15 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Emotion processing in youths with conduct problems: an fMRI meta-analysis.Translational psychiatry · 2023Pooled it
- Pupil-based arousal self-regulation: impact on physiological and affective responses to emotional stimuli.Translational psychiatry · 2026Article
- Understanding the developmental trajectory of behavioral problems and subcortical structure morphometry in healthy children at 6 years old and long-term impact of early nutrition: the COGNIS study.Child and adolescent psychiatry and mental health · 2026Article
- Multimodal correlates of socioemotional movie-watching and their associations with internalizing symptoms in childhood and adulthood.Social cognitive and affective neuroscience · 2026Article
- COVID-19 Pandemic Impacts on STRESS, PTSD, and Prefrontal Cortical Thickness in Pre-Pandemic Trauma Survivors.Journal of personalized medicine · 2025Article
- Unique versus shared neural correlates of externalizing psychopathology in late childhood.Journal of psychopathology and clinical science · 2024Article
- Does the Relationship between Age and Brain Structure Differ in Youth with Conduct Disorder?Research on child and adolescent psychopathology · 2024Article
- Transcranial alternating current stimulation ameliorates emotional attention through neural oscillations modulation.Cognitive neurodynamics · 2023Article
- From mother to child: How intergenerational transfer is reflected in similarity of corticolimbic brain structure and mental health.Developmental cognitive neuroscience · 2023Article
- Moral Thinking and Empathy in Cognitive Behavioral Therapy for Children and Adolescents with Conduct Problems: A Narrative Review.Clinical child and family psychology review · 2023Review
- Linking heart rate variability to psychological health and brain structure in adolescents with and without conduct disorder.Frontiers in psychiatry · 2023Article
- Prefrontal cortical thickness, emotion regulation strategy use and COVID-19 mental health.Social cognitive and affective neuroscience · 2022Article
- Large-scale functional brain networks of maladaptive childhood aggression identified by connectome-based predictive modeling.Molecular psychiatry · 2022Article
- Neural Correlates of Reactive Aggression in Adult Attention-Deficit/Hyperactivity Disorder.Frontiers in psychiatry · 2022Article
- Neuropsychological Subgroups of Emotion Processing in Youths With Conduct Disorder.Frontiers in psychiatry · 2020Article
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Authors and funding
11 authors at 5 institutions in 4 countries.
Funding
Abstract
backgroundConduct disorder (CD), which is characterized by severe aggressive and antisocial behavior, is linked to emotion processing and regulation deficits. However, the neural correlates of emotion regulation are yet to be investigated in adolescents with CD. Furthermore, it remains unclear whether CD is associated with deficits in emotional reactivity, emotion regulation, or both.
methodsWe used functional magnetic resonance imaging to study effortful emotion regulation by cognitive reappraisal in 59 female adolescents 15 to 18 years of age (30 with a CD diagnosis and 29 typically developing (TD) control adolescents).
resultsBehaviorally, in-scanner self-report ratings confirmed successful emotion regulation within each group individually but significant group differences in emotional reactivity and reappraisal success when comparing the groups (CD < TD). Functional magnetic resonance imaging results revealed significantly lower activation in left dorsolateral prefrontal cortex and angular gyrus in CD compared with TD adolescents during emotion regulation, but no group differences for emotional reactivity. Furthermore, connectivity between left dorsolateral prefrontal cortex and the bilateral putamen, right prefrontal cortex, and amygdala was reduced in CD compared with TD adolescents during reappraisal. Callous-unemotional traits were unrelated to neural activation, but these traits correlated negatively with behavioral reports of emotional reactivity.
conclusionsOur results demonstrate reduced prefrontal brain activity and functional connectivity during effortful emotion regulation in female adolescents with CD. This sheds light on the neural basis of the behavioral deficits that have been reported previously. Future studies should investigate whether cognitive interventions are effective in enhancing emotion-regulation abilities and/or normalizing prefrontal and temporoparietal activity in female adolescents with CD.
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