Evidence map›Paper›PMID 31311708›Full record

ReviewJournal of magnetic resonance (San Diego, Calif. : 1997)2019

Two decades of progress in structural and dynamic studies of amyloids by solid-state NMR.

Christopher P Jaroniec

Abstract readReview
In one paragraph

Review in Journal of magnetic resonance (San Diego, Calif. : 1997), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Chemical reviews · 2022
    Review
  9. Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Comparative study of the stabilities of syntheticThe Journal of biological chemistry · 2020
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Christopher P JaroniecDepartment of Chemistry and Biochemistry, The Ohio State University, 100 West 18th Avenue, Columbus, OH 43210, USA. Electronic address: jaroniec.1@osu.edu.

Funding

Structural determinants of amyloid strain heterogeneity in distinct phenotypes of Alzheimer's diseaseRF1AG061797 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI JARONIEC, CHRISTOPHER P, SAFAR, JIRI G. · 2018 to 2021
$4.4M
Molecular Mechanisms of Prion and Amyloid PropagationR01GM094357 · NIGMS · OHIO STATE UNIVERSITY · PI JARONIEC, CHRISTOPHER P · 2011 to 2022
$3.2M
Replication mechanism of human prionsR01NS103848 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI SAFAR, JIRI G., SUREWICZ, WITOLD K · 2018 to 2022
$2.6M
Structural and dynamic studies of histone tails in chromatin by magnetic resonance spectroscopyR01GM123743 · NIGMS · OHIO STATE UNIVERSITY · PI JARONIEC, CHRISTOPHER P, POIRIER, MICHAEL GUY · 2017 to 2018
$658k
NIA NIH HHS RF1 AG061797NIGMS NIH HHS R01 GM094357NIGMS NIH HHS R01 GM123743NINDS NIH HHS R01 NS103848
6 · The paper itself

Abstract

In this perspective article I briefly highlight the rapid progress made over the past two decades in atomic level structural and dynamic studies of amyloids, which are representative of non-crystalline biomacromolecular assemblies, by magic-angle spinning solid-state NMR spectroscopy. Given new and continuing developments in solid-state NMR instrumentation and methodology, ongoing research in this area promises to contribute to an improved understanding of amyloid structure, polymorphism, interactions, assembly mechanisms, and biological function and toxicity.

Indexed as

AmyloidAmyloidogenic ProteinsHumansNuclear Magnetic Resonance, BiomolecularProtein ConformationAmyloidAmyloidogenic ProteinsAmyloid fibrilsMagic-angle spinningProtein structure and dynamicsSolid-state NMR

Identifiers

PMID31311708
PMCPMC6703944

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.