Evidence map›Paper›PMID 31311690›Full record

ArticleInternational journal of hygiene and environmental health2019

Pesticide interactions and risks of sperm chromosomal abnormalities.

Zaida I Figueroa, Heather A Young, Sunni L Mumford, John D Meeker, Dana B Barr, George M Gray, Melissa J Perry

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of hygiene and environmental health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Metal-Organic Frameworks in Agriculture.ACS applied materials & interfaces · 2022
    Review
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Zaida I FigueroaGeorge Washington University, Milken Institute School of Public Health, Department of Environmental and Occupational Health, Washington, DC, USA.
Heather A YoungGeorge Washington University, Milken Institute School of Public Health, Department of Epidemiology and Biostatistics, Washington, DC, USA.
Sunni L MumfordNational Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Division of Intramural Population Health Research, Bethesda, MD, USA.
John D MeekerUniversity of Michigan, School of Public Health, Department of Environmental Health Sciences, Ann Arbor, MI, USA.
Dana B BarrEmory University, Rollins School of Public Health, Department of Environmental Health, Atlanta, GA, USA.
George M GrayGeorge Washington University, Milken Institute School of Public Health, Department of Environmental and Occupational Health, Washington, DC, USA.
Melissa J PerryGeorge Washington University, Milken Institute School of Public Health, Department of Environmental and Occupational Health, Washington, DC, USA. Electronic address: mperry@gwu.edu.
George Washington University · USMilken Institute · USEmory University · USUniversity of Michigan–Ann Arbor · US

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
PCBs, Phthalates and Male Reproductive HealthR01ES009718 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI HAUSER, RUSS B · 1999 to 2018
$11.6M
Environmental Endocrine Disruptors and Human Sperm Chromosomal AbnormalitiesR01ES017457 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI PERRY, MELISSA · 2010 to 2012
$971k
Intramural NIH HHS Z99 HD999999NIEHS NIH HHS P30 ES000002NIEHS NIH HHS R01 ES009718NIEHS NIH HHS R01 ES017457
6 · The paper itself

Abstract

Disentangling the separate and synergistic effects of chemicals poses methodological challenges for accurate exposure assessment and for investigating epidemiologically how chemicals affect reproduction. We investigated combined exposures to ubiquitous contemporary use pesticides, specifically organophosphates (OP) and pyrethroids (PYR), and their association with germ cell abnormalities among adult men. Fluorescence in situ hybridization was used to determine disomy in sperm nuclei and urine was analyzed for concentrations of PYR metabolites (3-phenoxybenzoic acid; 3PBA) and OP dialkyl phosphate (DAP) metabolites. Incidence rate ratios using Poisson models were estimated for each disomy type by exposure quartile of DAP metabolites and 3PBA, controlling for confounders. The shape of the associations between PYRs, OPs and disomy were frequently nonmonotonic. There were consistent interactions between OP and PYR metabolite concentrations and the risk for sperm abnormalities. Taking both chemicals into account simultaneously resulted in quantitatively different associations than what was reported previously for OPs and PYRs separately, demonstrating the importance of modeling multiple concentrations simultaneously. Methods investigating interactions using Poisson models are needed to better quantify chemical interactions and their effects on count-based health outcomes, the importance of which was shown here for germ cell abnormalities.

Indexed as

Chromosome AberrationsSpermatozoaAdultBiological MonitoringEnvironmental PollutantsHumansMaleOrganophosphatesPesticidesPyrethrinsRiskEnvironmental PollutantsOrganophosphatesPesticidesPyrethrinsAneuploidyEndocrine disruptorsIn situ hybridizationInteractionsPesticideReproduction

Identifiers

PMID31311690
PMCPMC7994026
OpenAlexW2957521185

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.